Synergistic delivery of 5-FU and thymoquinone via biogenic CaCO3 NPs in hyperglycemia-linked colorectal cancer cell
Prethiba K Ganasan a , Norsharina Ismail a,* , Ahmad Faizal Abdull Razis a,b , Md Zuki Bin Abu Bakar a,c & Kim Wei Chan a,*
a Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
b Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
c Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
CONTACT Kim Wei Chan mailto:chankim@upm.edu.my
Norsharina Ismail mailto:norsharina@upm.edu.my Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor
43400, Malaysia
Abstract
Aim This study evaluated two novel combination therapies using 5-Fluorouracil (5-FU), Thymoquinone (TQ), and cockle shell – derived calcium carbonate nanoparticles (CaCO3 NPs) against HT-29 colorectal cancer (CRC) cells under hyperglycemic conditions.
Methods 5-FU and TQ were successfully encapsulated into CaCO3 NPs through encapsulation at various drug-to-nanoparticle ratios. Physicochemical characterization was performed to...
