Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis
- Published on 03/03/2026
- Reading time: 9 min.
Song Jiahang 1, Li Pengzhu 2, Canis Martin 1, Unger Kristian 3, Haas Nikolaus Alexander 2, Gires Olivier 1
1 https://ror.org/05591te55 Department of Otorhinolaryngology LMU University Hospital, LMU Munich Munich Germany
2 https://ror.org/02jet3w32 Division of Pediatric Cardiology and Intensive Care University Hospital, LMU Munich Munich Germany
3 https://ror.org/02jet3w32 Department of Radiation Oncology University Hospital, LMU Munich Munich Germany
Abstract
Background Psychoactive substance use (PSU) and cancer are frequently observed comorbidities that have reciprocal influences and shared behavioral traits of the affected patients. While, e.g., nicotine and alcohol are major carcinogens in the etiology of lung and head and neck cancers, little is known about a shared overarching genetic architecture of PSU and cancer that may predispose individuals to both illnesses.
Methods Large-scale genome-wide association...
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