Differences in biochemical metabolism and cognitive function between bipolar I and bipolar II disorder
- Published on 05/05/2026
- Reading time: 6 min.
Zhang Rongxu 1, Huang Dong 1, Lai Shunkai 1, Wang Ying 2, Zhang Yiliang 1, He Jiali 1, Chen Guanmao 2, Yan Shuya 1, Chen Pan 2, Lu Xiaodan 1, Huang Xiaosi 1, Zhong Shuming 1, Jia Yanbin 1
1 https://ror.org/05d5vvz89 Department of Psychiatry First Affiliated Hospital, Jinan University 510630 Guangzhou China
2 https://ror.org/02xe5ns62 Medical Imaging Centre, First Affiliated Hospital Jinan University 510630 Guangzhou China
Abstract
Background This study aimed to characterise neurometabolic differences between bipolar disorder I (BD-I) and bipolar disorder II (BD-II), and to examine their associations with cognitive function.
Methods A total of 50 patients diagnosed with BD-I, 80 patients with BD-II, and 50 healthy controls (HCs) were recruited for this study. Metabolite concentrations—specifically N-acetylaspartate (NAA) and choline-containing compounds (Cho)—were measured...
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