Isolated Paramedian Pontine Reticular Formation (PPRF) syndrome in AQP4 antibody–positive neuromyelitis optica spectrum disorder: a case report
- Published on 02/27/2026
- Reading time: 2 min.
Terahara Manami , Hobara Takahiro , Higuchi Yujiro , Hirakata Shota , Noguchi Yutaka , Nozuma Satoshi , Takashima Hiroshi
https://ror.org/03ss88z23 Department of Neurology and Geriatrics Kagoshima University Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka 890-8520 Kagoshima City Kagoshima Japan
Abstract
Background Paramedian pontine reticular formation (PPRF) syndrome is characterized by horizontal gaze palsy due to lesions in the PPRF or the abducens nucleus. It is relatively rare and is typically associated with medial longitudinal fasciculus (MLF) syndrome.
Case presentation A 53-year-old Japanese woman presented with right lateral gaze palsy and facial nerve palsy, with preserved convergence and left lateral gaze. Neurological evaluation confirmed...
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