Cathepsin C correlates with M2 macrophage infiltration and regulates the tumor growth and metastasis in non-small cell lung cancer
- Published on 06/10/2025
- Reading time: 6 min.
Tong Xiaoxia 1, Zhu Ting 2, Ma Li 1, Yang Xiaohu 3, Li Chenghui 4, Liu Yibing 1,4, Qin Xuan 5, Ding Yanguang 5, Xia Hongwei 5, Liu Yonglei 1
1 https://ror.org/013q1eq08 Experimental Research Center Qingpu Hospital Affiliated to Fudan University 1158 Park Road(E) 201700 Shanghai Shanghai China
2 https://ror.org/013q1eq08 Department of Pathology Qingpu Hospital Affiliated to Fudan University Shanghai China
3 https://ror.org/013q1eq08 Department of Vascular Surgery Qingpu Hospital Affiliated to Fudan University Shanghai China
4 https://ror.org/013q1eq08 Department of General Surgery Qingpu Hospital Affiliated to Fudan University Shanghai China
5 https://ror.org/013q1eq08 Department of Thoracic Surgery Qingpu Hospital Affiliated to Fudan University Shanghai China
Abstract
Cathepsin C (CTSC) is a cysteine protease in lysosomes that controls immunological responses. Upregulation CTSC expression was reportedly related with tumor progression and metastasis. The roles and mechanisms of CTSC in non-small cell lung cancer (NSCLC) are still unclear. Through systematic analysis, we found that the level of CTSC was higher in NSCLC and it was correlated with the overall survival (OS) of NSCLC patients. Furthermore, single-cell sequencing (scRNA-seq) analysis...
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