Efficacy and safety of ruxolitinib cream for the treatment of moderate to severe chronic hand eczema: Results from a 16-week, multicenter, randomized, double-blind study

  • Published on 05/18/2026
  •  Reading time: 1 min.

Zirwas, Matthew; Fowler, Joseph F.; Tsianakas, Athanasios; Devani, Alim R.; Halden, Philippa; Lai, Zhihong; Kuo, YuTzu; Nawaz, Haq; Stein Gold, Linda F.

Abstract

Background Chronic hand eczema (CHE) is a well-recognized inflammatory disorder.
Objective To evaluate the efficacy and safety of 1.5% ruxolitinib cream in adults with moderate to severe CHE.
Methods This phase 2 study enrolled adults with CHE from North America and Europe, an Investigator's Global Assessment-CHE score of 3/4, 1 prior CHE therapy, and no current or recent history (5 y) of...

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