Diagnostic yield of upper gastrointestinal tract endoscopy and colonoscopy in patients with iron deficiency anaemia while on direct oral anticoagulants

Published on 01/03/2025

Reading time: 4 min.

Victor Ching ¹, Karen Hay ², Ivan Hui ³, Ann Vandeleur ⁴, Prisca Har ¹, Tony Rahman ⁴, Alaa Alghamry ^1,5

¹ Internal Medicine Services The Prince Charles Hospital Brisbane Queensland Australia
² Statistics Unit QIMR Berghofer Medical Research Institute Brisbane Queensland Australia
³ Department of General Medicine Hunter New England Local Health District Newcastle New South Wales Australia
⁴ Department of Gastroenterology and Hepatology The Prince Charles Hospital Brisbane Queensland Australia
⁵ Faculty of Medicine The University of Queensland Brisbane Queensland Australia

Abstract

Background Iron deficiency anaemia (IDA) related to occult gastrointestinal tract (GIT) blood loss is associated with high rates of GIT malignancies. Major society guidelines recommend bidirectional endoscopic evaluation for all men and post‐menopausal women with newly diagnosed, unexplained IDA. However, in patients prescribed direct oral anticoagulants (DOACs), the endoscopic yield, specifically the rate of high‐risk findings, including colorectal cancers...

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