Effective management of 5-fluorouracil-induced coronary vasospasm allowing chemotherapy continuation: a single-center observational study

  • Published on 07/27/2026
  •  Reading time: 1 min.

Kolossváry, Kinga; Heltai, Krisztina; Székely, Borbála; Rubovszky, Gábor

Abstract

Background: 5-fluorouracil (5-FU) is a widely used chemotherapy agent in gastrointestinal (GI) malignancies, but it can cause cardiotoxicity, most commonly manifesting as chest pain due to coronary vasospasm, often mimicking acute coronary syndrome. Adequate management of 5-FU-associated vasospasm is critical to ensure the necessary oncological treatment can be safely continued.

Objectives: The aim of this study was the retrospective analysis of cases...

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