Neurofilament Light Chain and Cognitive Dysfunction in Patients Undergoing Hemodialysis: A Cross-Sectional Exploratory Study.

  • Published on 07/29/2026
  •  Reading time: 1 min.

Kato, Kazuhiko; Nakashima, Akio; Shinagawa, Shunichiro; Kobayashi, Arisa; Ohkido, Ichiro; Urashima, Mitsuyoshi; Yokoo, Takashi

Abstract

* Blood biomarkers related to amyloid [beta] and neurofilament light chain are used to predict cognitive decline in the general population.

* Evidence for their usefulness is lacking in patients receiving hemodialysis despite their high risk of cognitive impairment.

* Neurofilament light chain levels were negatively associated with cognitive function, whereas the amyloid [beta] ratio was not.

Background: Cognitive dysfunction is frequently observed...

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