Real-Time ATP Imaging Reveals the Metabolic State during Branching Nephrogenesis.
- Published on 07/31/2026
- Reading time: 1 min.
Mii, Akiko; Yamamoto, Shinya; Yamamoto, Masamichi; Yamamoto, Shigenori; Fukuma, Shingo; Shimizu, Akira; Imamura, Hiromi; Yanagita, Motoko
Abstract
* Real-time ex vivo ATP imaging revealed spaciotemporal ATP dynamics of metanephric kidneys during nephrogenesis.
* Glycolytic inhibition reduced cytosolic ATP levels in ureteric bud and cap mesenchyme cells and suppressed ureteric bud branching.
* Ureteric bud cells were highly dependent on glycolysis, exhibiting faster and more pronounced ATP reduction by glycolytic inhibition than cap mesenchyme cells.
Background: Energy metabolism is fundamental...
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