Epicardial adipose tissue mediates the association between circulating hsa-miR-4750-3p and coronary artery disease in patients with type 2 diabetes mellitus
- Published on 05/04/2026
- Reading time: 11 min.
Szydełko Joanna 1, Zapolski Tomasz 2, Lenart-Lipińska Monika 1, Czop Marcin 3, Petniak Alicja 3, Kocki Janusz 3, Matyjaszek-Matuszek Beata 1
1 https://ror.org/016f61126 Department of Endocrinology, Diabetology and Metabolic Diseases Medical University of Lublin Jaczewskiego 8 20-090 Lublin Poland
2 https://ror.org/016f61126 Department of Cardiology Medical University of Lublin Jaczewskiego 8 20-090 Lublin Poland
3 https://ror.org/016f61126 Department of Clinical Genetics Medical University of Lublin Radziwillowska 11 20-080 Lublin Poland
Abstract
Background Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot contributing to coronary atherosclerosis, yet the molecular mechanisms underlying EAT-related coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) remain unclear. Previously, we identified novel circulating miRNAs targeting fatty acid metabolism in T2DM-CAD. This study aimed to investigate whether EAT may explain the association between dysregulated hsa-miR-4505, hsa-miR-4743-5p,...
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