MRI detects blood-brain barrier alterations in a rat model of Alzheimer’s disease and lung infection
- Published on 03/12/2025
- Reading time: 8 min.
Ohene Yolanda 1,2, Morrey William J. 2,4, Powell Elizabeth 3, Smethers Katherine F. 4, Luka Nadim 2,4, South Kieron 2,4, Berks Michael 5, Lawrence Catherine B. 2,4, Parker Geoff. J. M. 3,6, Parkes Laura M. 1,2, Boutin Hervé 2,4,7, Dickie Ben R. 2,5
1 https://ror.org/027m9bs27 Division of Psychology, Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health University of Manchester Manchester UK
2 https://ror.org/027m9bs27 Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre University of Manchester Manchester UK
3 https://ror.org/02jx3x895 Department of Medical Physics and Biomedical Engineering and Department of Neuroinflammation, Centre for Medical Image Computing UCL London UK
4 https://ror.org/027m9bs27 Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health University of Manchester Manchester UK
5 https://ror.org/027m9bs27 Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health University of Manchester Manchester UK
6 Bioxydyn Limited Manchester UK
7 Imaging Brain & Neuropsychiatry iBraiN Université de Tours, INSERM Tours France
Abstract
Pneumonia is a common infection in people suffering with Alzheimer’s disease, leading to delirium, critical illness or severe neurological decline, which may be due to an amplified response of the blood-brain barrier (BBB) to peripheral insult. We assess the response of the BBB to repeated Streptococcus pneumoniae lung infection in rat model of Alzheimer’s disease (TgF344-AD), at 13- and 18-months old, using dynamic contrast-enhanced (DCE) MRI and filter...
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