miR-92a as a potential biomarker and therapeutic target in heart failure: evidence from human and mouse studies
- Published on 03/02/2026
- Reading time: 3 min.
Zhu Luya 1, Li Yuqing 2, Pan Wenqi 3, Chen Jinru 1
1 Department of Cardiovascular Medicine Fuyang Hospital of Traditional Chinese Medicine 311400 Fuyang China
2 Hangzhou Fuyang District Traditional Chinese Medicine Hospital Office 311400 Fuyang China
3 https://ror.org/01hv94n30 Department of Cardiology, School of Medicine Ruijin Hospital, Shanghai Jiao Tong University 200025 Shanghai China
Abstract
Background This research investigated the expression of microRNA-92a (miR-92a) in chronic heart failure (CHF) patients and assessed its regulatory mechanism using a transverse aortic constriction (TAC) mouse model.
Methods Thirty patients with CHF (NYHA class II-IV) and 30 age and sex-matched healthy controls were enrolled from January 2021 to April 2022. Plasma levels of miR-92a were analyzed by quantitative reverse transcription polymerase chain reaction...
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