Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization study
- Published on 06/09/2025
- Reading time: 7 min.
Huang Xin 1, Zhao Jie V. 1,2
1 https://ror.org/02zhqgq86 School of Public Health, Li Ka Shing, Faculty of Medicine The University of Hong Kong Pokfulam Road Hong Kong SAR China
2 https://ror.org/02zhqgq86 State Key Laboratory of Pharmaceutical Biotechnology The University of Hong Kong Hong Kong Hong Kong SAR China
Abstract
Background Insulin is known to be associated with a higher risk of coronary artery disease (CAD), but molecular mechanisms remain unclear. This study aimed to explore protein-mediated pathways linking fasting insulin to CAD using Mendelian randomization (MR).
Methods This MR study examined the association between fasting insulin and CAD using genome-wide association study (GWAS) data from MAGIC and CARDIoGRAMplusC4D. To investigate underlying mechanisms,...
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