Enhancing systemic lupus erythematosus treatment outcomes with an early initiation of belimumab: insights from a multicenter retrospective study within the first five years
- Published on 06/06/2025
- Reading time: 4 min.
Kojima Kanako 1, Ichinose Kunihiro 1,2,3, Umeda Masataka 1, Shimizu Toshimasa 1, Sato Shuntaro 4, Suzuki Takahisa 5, Nakashima Yoshikazu 6, Okada Akitomo 7, Horai Yoshiro 8, Fujikawa Keita 9, Aramaki Toshiyuki 10, Miyashita Taiichiro 11, Furuyama Masako 6, Matsuoka Naoki 12, Kawakami Atsushi 1
1 https://ror.org/03ppx1p25 Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences Nagasaki University Graduate School of Biomedical Sciences 1-7-1 Sakamoto 852-8501 Nagasaki Japan
2 https://ror.org/01jaaym28 Department of Rheumatology, Faculty of Medicine Shimane University 89-1 Enya-Cho 693-8501 Izumo Japan
3 https://ror.org/01jaaym28 Integrated Kidney Research and Advance, Faculty of Medicine Shimane University Izumo Japan
4 https://ror.org/05kd3f793 Clinical Research Center Nagasaki University Hospital Nagasaki Japan
5 Japanese Red Cross Nagasaki Genbaku Hospital Nagasaki Japan
6 Nagasaki Kita Hospital Nagasaki Japan
7 https://ror.org/02qv90y91 National Hospital Organization Nagasaki Medical Center Omura Japan
8 https://ror.org/00hx9k210 Sasebo City General Hospital Sasebo Japan
9 https://ror.org/03q11y497 Japan Community Healthcare Organization, Isahaya General Hospital Isahaya Japan
10 https://ror.org/018bw0k35 Sasebo Chuo Hospital Sasebo Japan
11 Miyashita Rheumatology Clinic Omura Japan
12 Nagasaki Medical Hospital of Rheumatology Nagasaki Japan
Abstract
Background The human monoclonal antibody belimumab (BEL) has emerged as a promising treatment for systemic lupus erythematosus (SLE), particularly for reducing the need for glucocorticoids and minimizing organ damage. The optimal timing of BEL initiation has been unclear; emerging evidence suggests that early intervention with BEL, particularly within the first 5 years of diagnosis, may yield better outcomes by modulating disease progression and reducing flare...
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