Hippocampal subfields: volume, neuropathological vulnerability and cognitive decline in Alzheimer’s and Parkinson’s disease
- Published on 06/04/2025
- Reading time: 8 min.
Bouwman Maud M. A. 1,2,3, Frigerio Irene 1,2,3, Lin Chen-Pei 1,2,3, Reijner Niels 1,2,3, van de Berg Wilma D. J. 1,2, Jonkman Laura E. 1,2,3
1 https://ror.org/05grdyy37 Department of Anatomy and Neurosciences, Section Clinical Neuroanatomy and Biobanking Amsterdam UMC, location VUmc De Boelelaan 1118 Amsterdam The Netherlands
2 https://ror.org/01x2d9f70 Amsterdam Neuroscience Neurodegeneration, Amsterdam The Netherlands
3 https://ror.org/01x2d9f70 Amsterdam Neuroscience Brain imaging Amsterdam The Netherlands
Abstract
Background The hippocampus is highly affected in neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). The relationship between neuropathology and atrophy in hippocampal subfields is complex due to differences in the selective neuronal vulnerability to distinct protein aggregates that underlie cognitive impairment. The aim of the current study was to investigate the relation between hippocampal subfield volumes, neuropathological...
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