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Synergistic delivery of 5-FU and thymoquinone via biogenic CaCO3 NPs in hyperglycemia-linked colorectal cancer cell
Colorrectal
 1 min.

 Publicado el 09/12/2025 |  Artículo original (Full-text)  | Prethiba K Ganasan et al. | Therapeutic Delivery 2025; 16(11): 1055-1070

This study evaluated two novel combination therapies using 5-Fluorouracil (5-FU), Thymoquinone (TQ), and cockle shell – derived calcium carbonate nanoparticles (CaCO NPs) against HT-29 colorectal cancer (CRC) cells under hyperglycemic conditions. 5-FU and TQ were successfully encapsulated into...

Colorectal cancer in young: a 5-year study from a sub-Saharan African country
Colorrectal
 3 min.

 Publicado el 02/12/2025 |  Artículo original (Full-text)  | Boubacar Efared et al. | BMC Gastroenterology 2025; 25(1): 844

Colorectal cancer (CRC) is one of the most frequent malignancies worldwide, posing a major public health threat [1, 2]. According to the 2022 global cancer statistics CRC was the third most frequent cancer with 1,926,118 new cases, ranking as the second cancer in mortality with 903,859 deaths [1]. Colorectal...

Fruquintinib plus sintilimab in previously bevacizumab-treated, pMMR/MSS refractory metastatic colorectal cancer: a phase 2 clinical trial
Colorrectal
 5 min.

 Publicado el 25/11/2025 |  Artículo original (Full-text)  | Zhang Wen. et al. | Cancer Immunology, Immunotherapy 2025; 74(12): 381

Colorectal cancer (CRC) is the third most common cancer and the second most deadly cancer worldwide [1]. In China, colorectal cancer ranks as the fourth most common malignancy and accounted for approximately 240,000 deaths in 2022 [2]. In recent years, systemic chemotherapy combined with targeted therapy...

Comparative analysis of osteoporotic versus pathologic fracture in metastatic colorectal cancer patients
Colorrectal
 5 min.

 Publicado el 18/11/2025 |  Artículo original (Full-text)  | Park Jiwon et al. | Osteoporosis International 2025; 36(10): 1941-50

Colorectal cancer (CRC) is the third most prevalent malignancy worldwide [1]. Although the prognosis of patients with metastatic CRC (mCRC) is generally poor, recent developments in novel chemotherapeutic agents have increased the overall survival of patients to approximately 30 months [2]. In line with...