RORγ drives non-small cell lung cancer progression by upregulating the NGF signaling

  • Published on 03/03/2026
  •  Reading time: 6 min.

Zeng Yechun 1, Cai Guodi 1, Zhang Jian 2, Zhang Zhenhua 1, Yin Wenxin 3, Ou Tianmiao 1, Xu Meng 4, Li Jing 5, Kang Zhanfang 6, Bu Junguo 7, Wang Junjian 1,8, Huang Jie 9, Feng Weineng 4

1 https://ror.org/0064kty71 National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences Sun Yat-Sen University 510006 Guangzhou Guangdong China
2 https://ror.org/04tm3k558 Thoracic Surgery Department The Third Affiliated Hospital of Sun Yat-sen University No. 600, Tianhe Road, Tianhe District 510630 Guangzhou Guangdong China
3 https://ror.org/02vg7mz57 School of Life Sciences and Biopharmaceutics Guangdong Pharmaceutical University 510006 Guangzhou Guangdong China
4 https://ror.org/01cqwmh55 Foshan Key Laboratory of Precision Therapy in Oncology and Neurology, Department of Pulmonary Oncology The First People’s Hospital of Foshan 528000 Foshan Guangdong China
5 https://ror.org/0064kty71 School of Marine Sciences Sun Yat-sen University 519082 Zhuhai Guangdong China
6 https://ror.org/00zat6v61 Guangdong Engineering Technology Research Center of Urinary Continence and Reproductive Medicine The Affiliated Qingyuan Hospital (Qingyuan People’s Hospital), Guangzhou Medical University 511518 Qingyuan Guangdong China
7 https://ror.org/01vjw4z39 Department of Radiation Oncology, Zhujiang Hospital Southern Medical University 510280 Guangzhou Guangdong China
8 https://ror.org/0064kty71 Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development Sun Yat-Sen University 510006 Guangzhou Guangdong China
9 Guangdong Lung Cancer Institute Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University 510080 Guangzhou Guangdong China

Abstract

Background Lung cancer remains one of the most prevalent and lethal malignancies worldwide, with non-small cell lung cancer (NSCLC) representing the most common subtype—highlighting the critical need for novel therapeutic approaches. The retinoic acid receptor-related orphan receptor gamma (RORγ) has been implicated in various cancers, but its role and mechanism in NSCLC remain unclear.
Methods RORγ expression and its correlation with...

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