Antifungal prophylaxis among critically ill COVID-19 patients: a meta-analysis and systematic review
- Published on 03/02/2026
- Reading time: 4 min.
Xie Huaiya 1, Pan Siqi 1, Zhang Ze 2, Fan Junping 1, Zhang Hong 1, Wang Jinglan 1, Tian Xinlun 1
1 https://ror.org/02drdmm93 Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College No.1 Shuaifuyuan, Dongcheng District 100730 Beijing China
2 https://ror.org/04jztag35 Division of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College No.1 Shuaifuyuan, Dongcheng District 100730 Beijing China
Abstract
Background COVID-19-associated pulmonary aspergillosis (CAPA) affects a significant proportion of patients admitted to the ICU and is associated with increased mortality, underscoring the need for effective prophylaxis. While observational studies suggest a benefit from antifungal prophylaxis, its efficacy remains unconfirmed by randomized trials, and its impact on clinical outcomes is unclear.
Methods We conducted a systematic review and meta-analysis...
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