Early-life protein-bound skin ceramides help predict the development of atopic dermatitis
- Published on 06/09/2025
- Reading time: 1 min.
Chang, Chia-Lun; Berdyshev, Evgeny; Milanzi, Elasma; Lodge, Caroline J.; Lopez, Diego J.; Bronova, Irina; Koplin, Jennifer J.; Peters, Rachel L.; Tang, Mimi L.K.; Dharmage, Shyamali C.; Abramson, Michael J.; Hui, Jennie; Varigos, George; Perrett, Kirsten P.; Sasi, Arun; Perret, Jennifer L.; Su, John C.; Robinson, Paul D.; Leung, Donald Y.M.; Lowe, Adrian J.
Abstract
Background
Skin lipids are crucial components of the skin barrier. Individuals with atopic dermatitis (AD or eczema) have a different skin lipid profile from those without. However, whether altered skin lipids precede and predict the subsequent risk of AD remained unclear, especially for different AD phenotypes.
Objective We sought to examine the relationship between skin lipids and subsequent AD and AD phenotypes in infants.
Methods...
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