Blood gene expression of Toll-like receptors in SLE patients with lupus nephritis or neuropsychiatric systemic lupus erythematosus
- Published on 03/07/2025
- Reading time: 6 min.
Dudkova Marketa 1, Petrackova Anna 2, Radvansky Martin 3, Skacelova Martina 1, Videman Jakub 1, Manakova Jirina 2, Kraiczova Veronika Smotkova 2, Kudelka Milos 3, Smrzova Andrea 1, Langova Katerina 4, Mrazek Frantisek 2, Kriegova Eva 2, Horak Pavel 1,5
1 https://ror.org/04qxnmv42 Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc Czech Republic
2 https://ror.org/04qxnmv42 Department of Immunology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc Czech Republic
3 https://ror.org/05x8mcb75 Department of Computer Science, Faculty of Electrical Engineering and Computer Science Technical University of Ostrava Ostrava Czech Republic
4 https://ror.org/04qxnmv42 Department of Medical Biophysics, Czech Republic, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc Czech Republic
5 https://ror.org/01jxtne23 III. Interni Klinika - Nefrologicka Revmatologicka a Endokrinologicka, Fakultni Nemocnice Olomouc Zdravotniku 248/7 779 00 Olomouc Czech Republic
Abstract
Background To determine differences in the blood innate gene expression signatures of systemic lupus erythematosus (SLE) patients across various organ manifestations and disease activity, with a focus on lupus nephritis (LN) and central nervous system (CNS) involvement.
Methods Toll-like receptor family (TLR 1–10) mRNA expression was investigated in peripheral blood mononuclear cells from patients with SLE (n = 74) and healthy...
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