Efficacy and safety of HR020602 in combination with propofol in children receiving general anesthesia: a multicenter, phase 2 study
- Published on 05/04/2026
- Reading time: 5 min.
Zou Nan 1, Wang Xiaoling 2, Wang Fang 1, Zou Xiaohua 3, Wang Sai-ying 4, Shangguan Wangning 5, Lin Xuemei 6, Lei Qian 7, Yu Yonghao 8, Wang Zhiping 9, Tang Lei 10, Ding Yan 10, Zhang Jianmin 1
1 https://ror.org/013xs5b60 Department of Anesthesiology, Beijing Children’s Hospital Capital Medical University, National Centre for Children’s Health No. 56 South Lishi Road, Xicheng District Beijing China
2 https://ror.org/013xs5b60 Department of Pharmacy, Beijing Children’s Hospital Capital Medical University, National Centre for Children’s Health Beijing China
3 https://ror.org/02kstas42 Department of Anesthesiology The Affiliated Hospital of Guizhou Medical University Guiyang China
4 https://ror.org/05akvb491 Department of Anesthesiology The Third Xiangya Hospital of Central South University Changsha China
5 https://ror.org/0156rhd17 Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Key Laboratory of Pediatric Anesthesiology of Ministry of Education Wenzhou China
6 https://ror.org/007mrxy13 Department of Anesthesiology Sichuan University West China Second University Hospital Chengdu China
7 https://ror.org/01qh26a66 Department of Anesthesiology Sichuan Provincial People’s Hospital Chengdu China
8 https://ror.org/003sav965 Department of Anesthesiology, Tianjin Institute of Anesthesiology Tianjin Medical University General Hospital Tianjin China
9 https://ror.org/02kstas42 Department of Anesthesiology Affiliated Hospital of Xuzhou Medical University Xuzhou China
10 https://ror.org/04ayvvz32 Jiangsu Hengrui Pharmaceuticals Co., Ltd Shanghai China
Abstract
Background The objective of this study was to evaluate the efficacy and safety of esketamine hydrochloride injection (HR020602) in combination with propofol for the induction and maintenance of general anesthesia in children, providing additional support for the use of esketamine in pediatric patients.
Methods This phase 2 study (NCT04867343) was conducted in two stages. Stage 1 involved the evaluation of the optimal dosing, and stage 2 was a multicenter,...
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