Life‐threatening hemorrhage as defined by the critical administration threshold in nontraumatic critical bleeding: A descriptive observational study

Published on 09/02/2024

Reading time: 5 min.

Luke J. Matzek ^1,2, Andrew C. Hanson ³, Phillip J. Schulte ³, Kimberly D. Cureton ³, Daryl J. Kor ^1,4, Matthew A. Warner ^1,4

¹ Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota USA
² Department of Anesthesiology and Perioperative Medicine, Division of Critical Care Medicine Mayo Clinic Rochester Minnesota USA
³ Department of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota USA
⁴ Patient Blood Management Program Mayo Clinic Rochester Minnesota USA

Abstract

Background Evaluations of critical bleeding and massive transfusion have focused on traumatic hemorrhage. However, most critical bleeding in hospitalized patients occurs outside trauma. The purpose of this study was to provide an in‐depth description examining the critical administration threshold (CAT; ≥3 units red blood cells (RBCs) in a 1‐h period) occurrences in nontraumatic hemorrhage. This will assist in establishing the framework...

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