COMP promotes the progression of colorectal cancer by regulating epithelial mesenchymal transition
- Published on 11/11/2025
- Reading time: 7 min.
Huang He 1,2, Wang Lei 2, Gao Song 2, Wang Haijiang 3
1 https://ror.org/01p455v08 Xinjiang Medical University Xinyi Road 830000 Urumqi China
2 https://ror.org/04f970v93 Department of Gastroenterology Fifth Affiliated Hospital of Xinjiang Medical University 118 Henan West Road 830011 Urumqi China
3 https://ror.org/03r4az639 Department of Gastroenterology Third Affiliated Hospital of Xinjiang Medical University 118 Henan West Road 830011 Urumqi China
Abstract
Background Epithelial-mesenchymal transition (EMT) plays a crucial role in the progression and metastasis of colorectal cancer (CRC). This study investigates the molecular mechanisms of EMT and its prognostic biomarkers in CRC.
Methods Multi-omics bioinformatics analyses were conducted using CRC transcriptomic datasets from GEO and TCGA. EMT-related differentially expressed genes (EMT-DEGs) were identified and subjected to pathway enrichment and machine...
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