MicroRNA-510-3p alleviates endothelial dysfunction in a DOCA–salt rat model of hypertension by targeting phosphatase and tensin homolog and its signaling axis
- Published on 06/01/2026
- Reading time: 1 min.
K. Auxzilia Preethi a , Sushmaa Chandralekha Selvakumar a , Thangavel Muthusamy b & Durairaj Sekar a,*
a RNA Biology Lab, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS, Deemed to Be University), Chennai, India
b Cellular and Molecular Biochemistry Unit, Research and Development, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research (BIHER), Chennai, India
CONTACT Durairaj Sekar mailto:duraimku@gmail.com RNA Biology Lab, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India
Abstract
Essential hypertension, characterized by persistent elevation of blood pressure, is often associated with endothelial dysfunction (ED), marked by impaired endothelial activity. Despite advancements, the molecular mechanisms underlying ED in hypertension remain unclear. This study aimed to investigate the role of microRNA-510-3p (miR-510-3p) in regulating endothelial function through the PTEN/PI3K/AKT/eNOS signaling pathway and to evaluate its potential as a biomarker and potential...
To continue reading this article in Full-Text...
Peer-Reviewed Journals A-Z
Search | Advanced search
Get the latest news in Cardiology
Receive our newsletter to stay up to date with the latest news in Cardiology
