Association of brain MRI signatures with Alzheimer Disease CSF biomarkers
- Published on 04/09/2025
- Reading time: 4 min.
You Cheng 1, Karthik Gopinath 2, Benjamin Billot 3, Juan Eugenio Iglesias 4,5,6, Alexandra Touroutoglou 7,8, Pia Kivisäkk 1, Chao‐Yi Wu 1, Hiroko H Dodge 1, Bradley T. T Hyman 1, Steven E Arnold 1, Sudeshna Das 1
1 Massachusetts General Hospital, Harvard Medical School, Boston, MA USA
2 Massachusetts General Hospital, Charlestown, MA USA
3 Massachusetts Institute of Technology, Cambridge, MA USA
4 Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA
5 Centre for Medical Image Computing, University College London, London UK
6 Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA USA
7 Department of Neurology, Harvard Medical School, Boston, MA USA
8 Massachusetts General Hospital, Boston, MA USA
Abstract
Background The relationship between CSF measures of Alzheimer disease (AD) pathologies and their neurodegenerative signatures is not fully understood. This study seeks to employ machine learning approaches on clinical MRI data to identify patterns associated with amyloid and tau, aiming to guide diagnosis and therapeutic interventions.
Method We selected brain volumes that differed significantly between AD pathology and control groups. Then we utilized...
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