Intraoperatively preventive intraperitoneal perfusion chemotherapy with lobaplatin in colorectal cancer: a prospective, randomised, controlled, multicentre study

  • Published on 06/10/2025
  •  Reading time: 5 min.

Su Hao 1, Zhang Rui 2, Li Yunfeng 3, Li Yanke 4, Pei Wei 5, Jie Zhigang 6, Liu Zhimin 7, Huang Meijin 8, Zhuang Jing 9, Jiang Qian 10, Xie Ming 11, Wang Guiying 12, Zhang Wenbin 13, Liu Ming 14, Chen Jiansi 15, Wang Zejun 16, Wang Kang 17, Zhang Xinghong 18, Li Guoxin 19, Zeng Xiangfu 20, Li Xinxiang 21, Sun Xuejun 22, Wang Ju 23, Zeng Dongzhu 24, Zhuang Changlong 25, Zhou Haitao 5, Wang Xishan 5

1 https://ror.org/00nyxxr91 Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Peking University Cancer Hospital & Institute 100142 Beijing China
2 https://ror.org/032d4f246 Department of Colorectal Surgery Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Insititute 110042 Shenyang China
3 https://ror.org/025020z88 Department of Colorectal Surgery Yunnan Cancer Hospital 650000 Kunming China
4 https://ror.org/04wjghj95 Department of Anus and Intestine Surgery First Affiliated Hospital of China Medical University 110001 Shenyang China
5 https://ror.org/02drdmm93 Department of Colorectal Surgery, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Science and Peking Union Medical College 100021 Beijing China
6 https://ror.org/05gbwr869 Department of Colorectal Surgery the First Affiliated Hospital of Nanchang University 330000 Nanchang China
7 https://ror.org/04n3h0p93 Department of Laparoscopic Comprehensive Surgery Zibo Central Hospital 255000 Zibo China
8 https://ror.org/005pe1772 Department of Colon and Rectum Surgery Sixth Affiliated Hospital of Sun Yat-Sen University 510000 Guangzhou China
9 https://ror.org/043ek5g31 Department of General Surgery Henan Cancer Hospital 450000 Zhengzhou China
10 https://ror.org/03108sf43 Department of General Surgery Jiangsu Cancer Hospital 210000 Nanjing China
11 https://ror.org/00g5b0g93 Department of Gastrointestinal Surgery Afiliated Hospital of Zunyi Medical University 563000 Zunyi China
12 https://ror.org/01mdjbm03 The Second Department of Surgery The Fourth Hospital of Hebei Medical University 050000 Shijiazhuang China
13 https://ror.org/02qx1ae98 Gastrointestinal Tumor Surgery the First Affiliated Hospital of Xinjiang Medical University 830000 Urumqi China
14 https://ror.org/05jscf583 Department of General Surgery The Fourth Hospital of HARBIN Medical University 150000 Harbin China
15 https://ror.org/03dveyr97 Department of Gastrointestinal Surgery Guangxi Medical University Cancer Hospital 530000 Nanning China
16 https://ror.org/035y7a716 Department of Gastrointestinal Surgery Cancer Hospital Affiliated to Guizhou Medical University 550000 Guiyang China
17 https://ror.org/009czp143 Department of Gastrointestinal Surgery Sichuan Provincial People’s Hospital 610000 Chengdu China
18 Department of Gastrointestinal Surgery Heilongjiang Agricultural Reclamation General Hospital 150000 Harbin China
19 https://ror.org/050nfgr37 Cancer Center Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University 102218 Beijing China
20 https://ror.org/040gnq226 Department of General Surgery First Affiliated Hospital of Gannan Medical University 341000 Ganzhou China
21 https://ror.org/00my25942 Department of Colorectal Surgery Fudan University Shanghai Cancer Center 200025 Shanghai China
22 https://ror.org/02tbvhh96 Department of General Surgery The First Affiliated Hospital of Xi’an Jiaotong University 710000 Xi’an China
23 https://ror.org/02yng3249 Department of Gastrointestinal Surgery Inner Mongolia Autonomous Region People’s Hospital 010000 Hohhot China
24 https://ror.org/017z00e58 Department of General Surgery The Third Affiliated Hospital of Chongqing Medical University 404100 Chongqing China
25 Hainan Changan International Pharmaceutical Co., Ltd. 570100 Haikou China

Abstract

Background Peritoneal metastasis (PM) after radical surgery is an important cause of treatment failure in colorectal cancer (CRC). Intraoperative intraperitoneal perfusion chemotherapy may be an effective method for preventing postoperative PM in patients with CRC. This study aimed to explore the safety and feasibility of intraoperatively preventive intraperitoneal perfusion chemotherapy using lobaplatin for CRC.
Methods Between 12 December 2017 and 17...

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