Colorrectal: Archivos Noticias del mes
5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complexColorrectal 1 min.
Previous study showed the PARP inhibitor ABT-888 potentiates the cytotoxicity of 5-fluorouracil (5-FU) by inhibiting PARP1-mediated mismatch repair (MMR) pathway via MSH6 deregulation in MMR-proficient colorectal cancer stem cells (CRC-CSCs). Emerging evidence indicates 5-FU regulates O -methylguanine-DNA-methyltrans...
Tumour-Associated Neutrophils in Colorectal Cancer: a Systematic Review, Meta-analysis, and Comprehensive Literature ReviewColorrectal 1 min.
Neutrophils are at the forefront of innate immune response. The prognostic impact of tumour-associated neutrophils (TANs) remains unclear. This study aimed to evaluate the prognostic role of TANs in colorectal cancer (CRC). Methods: A systematic review and meta-analysis were conducted using PubMed, Embase,...
Validation of the fear of cancer recurrence inventory-short form in long-term colorectal cancer survivorsColorrectal 1 min.
The Fear of Cancer Recurrence Inventory-Short Form (FCRI-SF) is commonly used to categorize the severity of fear of cancer recurrence (FCR) defined as fear, worry, or concern about cancer returning or progressing. Evaluating the FCRI-SF factor structure and the clinical cut-off score in specific cancer...
Fungi and colorectal cancer: from dysregulation to clinical translationColorrectal 1 min.
Research on the gut microbiota has primarily focused on bacterial communities. However, the role of fungi-the second-largest eukaryotic component of the gut microbiome-in the development and progression of colorectal cancer (CRC) has been less extensively studied compared to bacteria. Recent studies...
Lipid metabolism as a central driver of immune remodeling and therapeutic vulnerability in metastatic colorectal cancerColorrectal 1 min.
Dysregulated lipid metabolism has emerged as a defining hallmark of colorectal cancer (CRC) progression, particularly in metastatic disease, where metabolic adaptation and immune evasion are tightly interconnected, as demonstrated in both murine models and human studies. Increasing evidence has demonstrated...
