Hemophilia A is a rare congenital bleeding disorder characterized by hemarthrosis, which is mostly observed in the knee, ankle and elbow joints [1]. Recurrent hemarthrosis eventually causes hemophilic arthropathy [2]. It can reduce functionality, especially in the lower extremities [3]. Furthermore,...
Heparin is an anticoagulant that is widely used to treat and prevent thromboembolism, prevent blood clotting while using extracorporeal circulation devices, including during hemodialysis and cardiopulmonary bypass, and prevent blood clotting during vascular catheter insertion. Heparin-induced thrombocytopenia...
Hemophilia is a rare X-linked recessive hereditary bleeding disorder [1], characterized by recurrent joint bleeds, which may be complicated by hemophilic synovitis and arthritis [2]. Osteoporosis (OP) is a common comorbidity in patients with hemophilia(PWH). A study has shown that 27% of PWH have OP...
Hemophilia A is an X- chromosome hereditary hemorrhagic disease, characterized by quantitative or qualitative deficiency of coagulation factor VIII (FVIII), and causative mutations in the F8 coding gene were identified in about 95 − 98% HA patients [1, 2, 3–4], located on...
Hematological changes, including significant changes in blood volume, take place throughout pregnancy to meet the needs of the growing fetus and placenta. The direct effects of progesterone and estrogen on the kidney, which result in the release of renin and the activation of the aldosterone renin-angiotensin...