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Neuroendocrinology: Archives News of the month

Targeting RACGAP1 suppresses growth hormone pituitary adenoma growth

 Published on 03/04/2025 |  Original article (Abstract)  | Feifan Sun et al. | Endocrine 2024; 88(1): 234-48

Pituitary adenomas (PAs) are common lesions in humans, which are found in 15-20% of cadavers or radiologic findings and constitute approximately 10% of all intracranial tumors [1, 2]. PAs are usually classified into nonfunctioning adenomas and functional adenomas based on their ability to secrete hormones....

Primary ovarian neuroendocrine neoplasia with concurrent large epithelial borderline ovarian tumor, coexistent with non-malignant pleural effusion and multiple uterine fibroids: a case report and review of the literature

 Published on 27/03/2025 |  Original article (Abstract)  | Mohsin Mariam et al. | Journal of Medical Case Reports 2025; 19(1): 125

Neuroendocrine neoplasms (NENs) are a group of neoplasms often originating from the neuroendocrine cells in the gastrointestinal tract, pancreas, and respiratory tract from the tracheobronchial system. NENs arise from the endocrine cells derived from the neuroectoderm, neural crest, and endoderm [1,...

Endoscopic resection of rectal neuroendocrine tumors: zero disease-related deaths during a 10-year follow-up period

 Published on 20/03/2025 |  Original article (Abstract)  | Hayashi Yasuyo et al. | BMC Gastroenterology 2025; 25(1): 155

Gastrointestinal neuroendocrine tumors (GI-NETs), which originate from neuroendocrine cells in the deep mucosal layer and were referred to as benign carcinoid tumors [1], are now classified as neuroendocrine neoplasms with metastatic potential [2, 3–4]. Consequently, GI-NETs detected by endoscopic...

Relationship between MRI features and HIF-1α, GLUT1 and Ki-67 expression in pituitary adenoma with cystic degeneration

 Published on 13/03/2025 |  Original article (Abstract)  | Zhang Fangfang et al. | BMC Medical Imaging 2025; 25(1): 76

Pituitary adenoma (PA), a common tumor of the sellar region, is characterized by ischemia and hypoxia due to high proliferation and hypermetabolism, which can lead to changes of hemorrhage, necrosis, or cystic degeneration [1]. PA is frequently characterized by ischemia and hypoxia, and cystic transformation...

Immunohistochemical expression of ephrin receptors in neuroendocrine neoplasms: a case-series of gastroenteropancreatic neuroendocrine neoplasms and a systematic review of the literature

 Published on 06/03/2025 |  Original article (Abstract)  | Krystallenia I. Alexandraki et al. | Endocrine 2024; 87(3): 1323-32

Neuroendocrine neoplasms (NENs) represent a heterogeneous group of neoplasms originating from neuroendocrine cells of the endocrine system [1]. These neoplasms present a rising incidence all over the world, but the standard therapeutic strategies remained unchanged in the past decade, despite the rising...