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Ro5-4864, a translocator protein ligand, regulates T cell-mediated inflammatory responses in skin

 Published on 24/11/2025 |  Original article (Full-text)  | Yuka Sendai et al. | International Immunology 2025; 37(4): 221-34

Translocator protein (TSPO) is a mitochondrial outer membrane protein expressed on a variety of immune cells, including macrophages, dendritic cells, and T cells, in addition to neurons and steroid-producing cells. Previous studies of TSPO ligands have suggested that TSPO is involved in multiple cellular...

Nurturing Youth: Ethical Considerations in Pediatric Skincare Marketing

 Published on 17/11/2025 |  Original article (Full-text)  | Monisha Madhumita et al. | Pediatric Dermatology 2024; AOP: 10.1111/pde.15796

In the age of “Sephora Kids” and parental requests for skincare routines, children and preteens are diving headfirst into the world of skincare cosmetics, with concerns about skin lightening and even anti‐aging creeping into their skincare vocabulary [1]. But behind the glossy, colorful...

Vitamin D and the aging skin: insights into oxidative stress, inflammation, and barrier function

 Published on 10/11/2025 |  Original article (Full-text)  | Gao Hanlin et al. | Immunity & Ageing 2025; 22(1): 49

The extension of human lifespan represents a major achievement of modern medicine and public health [1]. According to the United Nations’ 2024 World Population Prospects, the global population aged 65 years and older surpassed 850 million in 2024 and is projected to reach 1.6 billion by 2054, with...

Unsuspected Malignant Mimicry From Topical Vitamin E and Micro Spike Roller

 Published on 03/11/2025 |  Original article (Full-text)  | Jacob Hauser et al. | Head & Neck 2025; 47(2): E28-E31

The anti‐aging product market has rapidly increased over recent years and is projected to become a 71‐billion‐dollar industry by 2031 [1]. Popular products in the form of ointments or creams often contain hyaluronic acid, various vitamin isoforms, and protein filament compounds advertised...

Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study.

 Published on 08/09/2025 |  PubMed  | Khashei Varnamkhasti Samire et al. | BMC geriatrics 2025 May; 25(1): 307

Oxidative damage is the principal cellular disturbance in the skin aging. Missense polymorphisms strengthen or weaken detoxification enzyme activity. Determination of deleterious functional effects of polymorphisms in detoxification genes (NQO1 and EPHX1) in skin aging was the overall purpose of conducting...