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Skin aging: mechanisms, evaluation, and rejuvenation

 Published on 20/07/2026 |  Original article (Full-text)  | Li, Runhan et al. | The EMBO journal. Volume 45(14).

Skin aging, the most visible and accessible manifestation of organismal aging, reflects systemic physiological decline, compromising barrier integrity, immune defense, and regenerative capacity-functions essential for overall tissue homeostasis and longevity. Understanding why and how the skin ages offers...

Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study.

 Published on 08/09/2025 |  PubMed  | Khashei Varnamkhasti Samire et al. | BMC geriatrics 2025 May; 25(1): 307

Oxidative damage is the principal cellular disturbance in the skin aging. Missense polymorphisms strengthen or weaken detoxification enzyme activity. Determination of deleterious functional effects of polymorphisms in detoxification genes (NQO1 and EPHX1) in skin aging was the overall purpose of conducting...

Pollution, a Relevant Exposome Factor in Skin Aging and the Role of Multi-benefit Photoprotection.

 Published on 01/09/2025 |  PubMed  | Santamaria J et al. | Actas dermo-sifiliograficas 2025 Jun; 116(6): 611-620

Skin aging is a complex, continuous, multifactorial process resulting from cumulative morphological and functional changes in the skin over time. This happens because of two processes: intrinsic and extrinsic skin aging. Intrinsic skin aging occurs naturally over time and reflects each person's genetic...