VirusArchives
Global burden of HIV and drug-resistant tuberculosis co-infection and its attributable risk factors, 1990 to 2021, with projections to 2031
Virus 4 min.
Multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR-TB) represent a critical antimicrobial resistance threat, significantly compromising treatment efficacy and overwhelming healthcare systems in endemic regions [1, 2]. Compared to drug-susceptible tuberculosis (TB) (more than 85%...
SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes
Virus 7 min.
COVID-19 patients continue to experience neurological and mental health-related symptoms ranging from cognitive impairments, such as brain fog, to mental health disorders, including anxiety and depression, beyond the acute phase of SARS-CoV-2 infection [1, 2, 3, 4, 5, 6, 7, 8, 9–10]. This is known...
Gut infection and dysbiosis are hallmarks of severe SARS-CoV-2 variants
Virus 6 min.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, first emerged in Wuhan, China, in December 2019 and rapidly spread worldwide, leading to over 7 million deaths to date.1 SARS-CoV-2 is an enveloped, single-stranded, positive-sense RNA virus2, whose entry into...
Comprehensive evaluation of NAT+/HBsAg– blood donors: confirmation strategies, serial testing outcomes, and S gene mutations associated with occult HBV infection
Virus 7 min.
Hepatitis B virus (HBV) infection remains a significant global health concern, with an estimated 296 million people chronically infected in 2019 [1]. HBV can be transmitted through transfusion, vertical transmission, sexual contact, and unsafe injections [2]. Therefore, rigorous blood screening for HBV...
