Other Cancers & Solid tumorsArchives
Nationwide trends in childhood cancer incidence and survival in Iran: analysis of national cancer registry data, 2005–2014
Other Cancers & Solid tumors 9 min.
Cancer remains a leading cause of death among children worldwide, with an estimated 206,362 new cases and 80,104 deaths in 2020 among those aged 0–14 years [1]. Childhood cancers are typically fatal without early diagnosis and treatment [2]. They account for about 1% of all cancers in high-income...
Leveraging large language models to extract smoking history from clinical notes for lung cancer surveillance
Other Cancers & Solid tumors 8 min.
Smoking is a significant risk factor for a range of health outcomes and remains the leading cause of preventable death in the United States1. Smoking increases the risk of developing lung2, breast3, head and neck4, pancreatic5, and other cancers6. Among cancer patients, continued smoking after diagnoses...
RNA m5C methylation in cancer: mechanisms and biological impact
Other Cancers & Solid tumors 8 min.
Epigenetics has transformed our understanding of gene regulation and cellular identity by focusing on modifications beyond the DNA sequence itself [1, 2]. These modifications regulate gene transcription, splicing, stability, and chromatin structure, influencing both physiological and pathological cellular...
Anoikis resistance and cancer
Other Cancers & Solid tumors 7 min.
Anoikis is defined as programmed cell death occurring when cells lack appropriate integrin-matrix interactions, for example, in conditions of detachment. Cell-matrix detachment occurs at impressive rates to maintain homeostatic cell numbers; notably, the gastrointestinal tract lining is replaced in its...
