Codeine is a weak opioid analgesic often found in low-dose combinations for the short-term treatment of acute pain. Croatia is one of the European Union (EU) countries where low-dose codeine products (LDCP) can be purchased over the counter (OTC) directly from community pharmacists without a prescription....
Opioid addiction has emerged as a significant socioeconomic and health issue, underscored by a notable increase in overdose-related fatalities [1, 2–3]. Thus, it is imperative to investigate the molecular and functional mechanisms underlying opioid addiction to develop therapeutic substitutes....
Opioid addiction is a global epidemic. In 2021, an estimated 60 million people used illicit opioids globally [1]. In 2019, opioids accounted for over 89,000 deaths globally. Fatal opioid overdoses were estimated to be over 80,000 in the United States alone in 2021 [2]. Approximately one million...
With the development of digital devices, mobile phones are omnipresent and have brought great convenience to social life. According to the 55th Statistical Report on Internet Development in China, as of December 2024, mobile phone internet users in China reached 1.108 billion, representing 99.73%...