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Bipolar DisordersArchives

Somatic morbidity in bipolar disorders

 Published on 23/06/2026 |  Original article (Full-text)  | Takami, Christine et al. | International Journal of Bipolar Disorders. Volume 14(1).

This Swedish nationwide cohort study used large-scale data to investigate the associations between bipolar disorder and somatic disorders and whether these risks differ by subtype, sex, or exposure to compulsory care. Methods: 61,071 individuals diagnosed with bipolar disorder in inpatient (from 1973)...

Speech analysis for differentiating bipolar disorder and major depressive disorder during euthymic states

 Published on 16/06/2026 |  Original article (Full-text)  | Lai, Jhen-Wu et al. | Annals of General Psychiatry. Volume 25(1).

Differentiating major depressive disorder (MDD) from bipolar disorder (BP) is crucial for early diagnosis and targeted treatment. This study investigates speech, linguistic biomarkers, and machine learning models to differentiate between the MDD and BP patients using speech analysis during symptom-free...

A transdiagnostic niacin flushing biomarker with disorder-specific multivariate relationships in adolescent unipolar and bipolar depression

 Published on 09/06/2026 |  Original article (Full-text)  | Feng Mengyao et al. | BMC Psychiatry 2026; 26(1): 131

Depressive episodes occur within the clinical course of both bipolar depression (BD) and major depressive disorder (MDD, or unipolar depression, UD), with a frequent and often under-recognized adolescent onset [1]. Furthermore, both disorders often lead to serious social and educational impairments,...

A novel sequential ketamine and D-cycloserine/lurasidone therapy for bipolar depression with acute suicidal ideation

 Published on 02/06/2026 |  Original article (Full-text)  | Mina Takahashi et al. | Expert Opinion on Investigational Drugs 2026; 35(5): 315-322

Bipolar depression with acute suicidal ideation and behavior (ASIB) is a life- threatening manifestation of bipolar disorder (BD), with a suicide risk higher than that in other psychiatric disorders and the general population. Rapid and effective interventions are critical, as traditional therapies are...