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Animal models that mirror bipolar disorder's pathophysiologic complexities: focused review of common models

 Published on 26/05/2026 |  Original article (Full-text)  | Ramy Yassa et al. | Expert opinion on drug discovery 2026; aop:10.1080/17460441.2026.2671292

It is difficult to model bipolar disorder in animals because the illness has opposed behavioral expressions and a multitude of associated pathophysiologic anomalies. The authors undertook a focused narrative review. The authors searched PubMed for all animal models of mania or bipolar disorder but focused...

A study protocol for the feasibility and acceptability of a personalized early intervention combining light therapy, lifestyle psychoeducation, and imagery-focused cognitive therapy in individuals at risk for bipolar disorder

 Published on 19/05/2026 |  Original article (Full-text)  | Treffers Else et al. | International Journal of Bipolar Disorders 2026; 14(1): 8

Bipolar Disorder (BD) is a severe mental illness (SMI) affecting approximately 2–3% of the general population and is associated with a significantly reduced life expectancy, often by as much as 20 years (Faedda et al. 2015). Despite its substantial impact, a clearly defined at-risk mental...

Prevalence of schizophrenia spectrum and bipolar disorder among patients with cannabis induced psychosis: a systematic review and meta-analysis

 Published on 12/05/2026 |  Original article (Full-text)  | Javed Mohammad Saad et al. | BMC Psychiatry 2025; 26(1): 185

Substance-induced psychosis (SIP) is characterized by the occurrence of delusions and/or hallucinations following the consumption or withdrawal of a recently ingested psychoactive substance [1]. It is distinguished from organic psychoses, such as those classified under the schizophrenia spectrum disorder...

Differences in biochemical metabolism and cognitive function between bipolar I and bipolar II disorder

 Published on 05/05/2026 |  Original article (Full-text)  | Zhang Rongxu et al. | BMC Psychiatry 2025; 26(1): 189

Bipolar disorder (BD) is a serious and persistent mood disorder that significantly impairs patients’ social functioning and quality of life [29]. It ranks among the leading causes of disability worldwide [35]. According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition...