Bipolar DisordersArchives
Transcriptomic Analysis of the Amygdala in Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder Reveals Differentially Altered Metabolic Pathways
Bipolar Disorders 1 min.
The amygdala, crucial for mood, anxiety, fear, and reward regulation, shows neuroanatomical and molecular divergence in psychiatric disorders like schizophrenia, bipolar disorder and major depression. This region is also emerging as an important regulator of metabolic and immune pathways. The goal of...
Cortical Transcriptomic Profiling Reveals Cellular and Mitochondrial Adaptive Stress Signatures That Differ Between Schizophrenia and Bipolar Disorder
Bipolar Disorders 1 min.
Identifying the nature of mitochondrial perturbations in brain regions dysfunctional in schizophrenia (SZ) and bipolar disorder (BP) is essential to decipher their disease processes. Employing "threshold-free" analytical approaches that evaluate patterns of gene expression differences and functional...
Disrupted Structural Covariance in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
Bipolar Disorders 1 min.
Shared clinical features and genetic factors in schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) have led to the hypothesis of common pathophysiological mechanisms. This study aims to elucidate aberrant transdiagnostic structural covariance patterns across these disorders...
Behavioral, cellular, and molecular changes in two animal models of bipolar disorder mania: sleep deprivation-induced mice and
Bipolar Disorders 1 min.
Sleep disturbances are prevalent in bipolar disorder (BD) patients, and the circadian locomotor output cycles kaput (Clock) gene plays a significant role in this process. The role of microglia (the brain-resident immune cells) in mediating this process remains uncertain. In this study, our findings showed...
Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum
Bipolar Disorders 1 min.
Negative symptoms of schizophrenia (SCZ), particularly amotivation, are prominent across both SCZ and bipolar disorder (BD). While orbitofrontal cortex (OFC) alterations have been implicated in the development of negative symptoms, their contributions across disorders remain to be established. Here,...
