Bipolar DisordersArchives
Cell-type specific reductions in interneuron gene expression within the cingulate gyrus of schizophrenia and bipolar disorder subjects
Bipolar Disorders 6 min.
The cingulate gyrus is a functionally heterogeneous cortical structure that mediates various forms of neurocognition including psychomotor control, attention, and memory processing1,2 which are reported to be compromised in schizophrenia (SZ) and bipolar disorder (BP)3,4. Coordination of cognitive domains...
Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease
Bipolar Disorders 1 min.
Postpartum mood disorders are heterogenous disorders and comprise postpartum psychosis and postpartum depression. Evidence is accumulating that systemic monocyte/macrophage activation, low-grade inflammation and (premature senescence related) T cell defects increase the risk for mood disorders outside...
Pharmacogenomics and response to lithium in bipolar disorder
Bipolar Disorders 1 min.
The present review explores the existing evidence on pharmacogenomic tests for prediction of lithium response in the treatment of bipolar disorder. We focused our research article on reports describing findings from genome-wide association studies, polygenic risk scores, and gene expression analyses...
The Swedish bipolar collection (SWEBIC)
Bipolar Disorders 6 min.
Bipolar disorder is characterised by episodes of mania and depression interspersed with periods of remission. The condition is highly heritable (~ 60–85%) (Lichtenstein, et al. 2009; McGuffin, et al. 2003) and first-degree relatives to index cases suffer eight times higher risk of developing bipolar...
