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Bipolar and major depressive disorders: associations with serum zonulin levels and rs2070937 polymorphism

 Published on 18/11/2025 |  Original article (Full-text)  | Baykan Ozgur et al. | BMC Psychiatry 2025; 25(1): 1086

Mood disorders are a major global cause of disability, morbidity, and mortality [1]. Among them, major depressive disorder (MDD) and bipolar disorder (BD) are the most prevalent, characterized by emotional and cognitive impairments that substantially limit daily functioning and reduce quality of life...

Differential microRNA profiling of blood L1CAM and bulk extracellular vesicles in bipolar disorder

 Published on 11/11/2025 |  Original article (Full-text)  | Gabriel R. Fries et al. | Epigenomics 2025; aop:10.1080/17501911.2025.2583894

This preliminary study aimed to identify microRNA (miRNA) signatures associated with bipolar disorder (BD) by profiling blood-derived extracellular vesicles (EVs) of both putative neuronal origin and from all sources. In two parallel studies of individuals with BD and controls (CON), we characterized...

Neuroendocrine abnormalities as predictors of suicidal ideation in bipolar disorder patients during depressive episodes: a cross-sectional study

 Published on 04/11/2025 |  Original article (Full-text)  | Fan Xiaoxuan et al. | BMC Psychiatry 2025; 25(1): 1029

Bipolar disorder (BD) is a common psychiatric disorder characterized by manic or hypomanic episodes and depressive episodes, with the latter being a typical feature. According to the WHO’s Mental Health Survey, BD has a global prevalence of 2.4%[1], making it one of the leading causes of disability...

Differences in event-related potentials between unipolar depression and bipolar II disorder during depressive episodes: a retrospective case-control study

 Published on 28/10/2025 |  Original article (Full-text)  | Zhou Xiaobo et al. | BMC Psychiatry 2025; 25(1): 1013

Bipolar II disorder (BD II) is a chronic and severe psychiatric condition characterized by recurrent major depressive episodes alternating with hypomanic episodes. A nationwide epidemiological study [1] reported a lifetime prevalence of 0.09% for bipolar I disorder and 0.04% for bipolar II disorder...