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Bipolar DisordersArchives

Differences in event-related potentials between unipolar depression and bipolar II disorder during depressive episodes: a retrospective case-control study

 Published on 28/10/2025 |  Original article (Full-text)  | Zhou Xiaobo et al. | BMC Psychiatry 2025; 25(1): 1013

Bipolar II disorder (BD II) is a chronic and severe psychiatric condition characterized by recurrent major depressive episodes alternating with hypomanic episodes. A nationwide epidemiological study [1] reported a lifetime prevalence of 0.09% for bipolar I disorder and 0.04% for bipolar II disorder...

Discrimination of first-onset patients with bipolar disorder or major depressive disorder using screened biochemical parameters

 Published on 21/10/2025 |  Original article (Full-text)  | Zhu Yuncheng et al. | Annals of General Psychiatry 2025; 24(1): 61

Psychiatric diagnoses have historically relied on on empirical symptom patterns, yet the consistency of bipolar disorder (BD) diagnosis continues to confront substantial challenges of inaccurate treatment and adverse patient outcomes [1]. Especially, the diagnosis and clinical differentiation of BD and...

Investigating seasonal metabolic variations in bipolar disorder: a targeted metabolomics study

 Published on 14/10/2025 |  Original article (Full-text)  | Li Xue et al. | BMC Psychiatry 2025; 25(1): 941

Bipolar disorder (BD) is a severe and disabling psychiatric disorder characterized by alternating episodes of mania and depression [1]. The global prevalence of BD varies between 1 And 2% [2], leading to a significant economic burden on both individuals and society [3]. Evidence suggests that seasonal...

Acquired bipolar cell disorder presenting with photophobia

 Published on 07/10/2025 |  Original article (Full-text)  | Igawa Yuro et al. | BMC Ophthalmology 2025; 25(1): 525

Cases have been recently reported in Japan of middle-aged and older individuals who have a sudden onset of photophobia and mixed negative electroretinograms (ERGs). The amplitude of the a-wave was normal but the rod, cone, and flicker responses were markedly reduced. Night blindness was a rare complaint...