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A novel sequential ketamine and D-cycloserine/lurasidone therapy for bipolar depression with acute suicidal ideation

 Published on 02/06/2026 |  Original article (Full-text)  | Mina Takahashi et al. | Expert Opinion on Investigational Drugs 2026; 35(5): 315-322

Bipolar depression with acute suicidal ideation and behavior (ASIB) is a life- threatening manifestation of bipolar disorder (BD), with a suicide risk higher than that in other psychiatric disorders and the general population. Rapid and effective interventions are critical, as traditional therapies are...

Animal models that mirror bipolar disorder's pathophysiologic complexities: focused review of common models

 Published on 26/05/2026 |  Original article (Full-text)  | Ramy Yassa et al. | Expert opinion on drug discovery 2026; 21(6): 609-621

It is difficult to model bipolar disorder in animals because the illness has opposed behavioral expressions and a multitude of associated pathophysiologic anomalies. The authors undertook a focused narrative review. The authors searched PubMed for all animal models of mania or bipolar disorder but focused...

A study protocol for the feasibility and acceptability of a personalized early intervention combining light therapy, lifestyle psychoeducation, and imagery-focused cognitive therapy in individuals at risk for bipolar disorder

 Published on 19/05/2026 |  Original article (Full-text)  | Treffers Else et al. | International Journal of Bipolar Disorders 2026; 14(1): 8

Bipolar Disorder (BD) is a severe mental illness (SMI) affecting approximately 2–3% of the general population and is associated with a significantly reduced life expectancy, often by as much as 20 years (Faedda et al. 2015). Despite its substantial impact, a clearly defined at-risk mental...

Prevalence of schizophrenia spectrum and bipolar disorder among patients with cannabis induced psychosis: a systematic review and meta-analysis

 Published on 12/05/2026 |  Original article (Full-text)  | Javed Mohammad Saad et al. | BMC Psychiatry 2025; 26(1): 185

Substance-induced psychosis (SIP) is characterized by the occurrence of delusions and/or hallucinations following the consumption or withdrawal of a recently ingested psychoactive substance [1]. It is distinguished from organic psychoses, such as those classified under the schizophrenia spectrum disorder...

Differences in biochemical metabolism and cognitive function between bipolar I and bipolar II disorder

 Published on 05/05/2026 |  Original article (Full-text)  | Zhang Rongxu et al. | BMC Psychiatry 2025; 26(1): 189

Bipolar disorder (BD) is a serious and persistent mood disorder that significantly impairs patients’ social functioning and quality of life [29]. It ranks among the leading causes of disability worldwide [35]. According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition...