BreastArchives
A Genetic Epidemiologic Investigation of Breast Cancer in Families With Bilateral Breast Cancer. I. Segregation Analysis
Breast 1 min.
A complex segregation analysis was conducted of breast cancer in 200 families with bilateral breast cancer. Results for two analyses are presented. The first analysis considered only premenopausal cases of breast cancer as affected. The results indicate that mendelian transmission of a single locus is...
ToPCourT protocol: a phase II trial of trilaciclib, pembrolizumab, gemcitabine, and carboplatin in locally advanced/unresectable or metastatic triple-negative breast cancer
Breast 1 min.
Triple-negative breast cancer (TNBC) is a clinically aggressive and difficult to treat malignancy. It has a poorer prognosis when compared to the hormone receptor (HR)-positive and human epidermal growth factor receptor type 2 (HER2)-positive subtypes. Due to the lack of targetable receptors, cytotoxic...
Injectable etoposide-loaded dextran nanoparticles for breast cancer treatment: physicochemical characterization, cytotoxicity studies, macrophage activity, and gene expression profiling
Breast 1 min.
This study aimed to develop and characterize injectable etoposide-loaded dextran sulfate sodium nanoparticles (ETP-DNPs). ETP-DNPs were prepared by ionic gelation and characterized. In vitro drug release was studied for 8 h, cytotoxicity was assessed in MCF-7 breast cancer cells, macrophage activation...
Targeting the transferrin receptor in breast cancer: nanotechnology-based drug delivery strategies
Breast 1 min.
Breast cancer remains a leading cause of cancer-related morbidity and mortality worldwide, with treatment efficacy often limited by systemic toxicity, poor tumor selectivity, and multidrug resistance. Nanotechnology-based drug delivery systems offer a promising strategy to enhance therapeutic precision,...
A complete pathological response to preoperative chemotherapy in a male patient with primary neuroendocrine breast cancer: a case report
Breast 2 min.
Globally, breast cancer is the second most commonly diagnosed cancer, while in Syria it represents the most prevalent cancer (21.5% of all cases in both sexes) [1, 2]. Less than 1% of all breast cancer cases occur in men [3]. Invasive ductal carcinoma is the most frequent histologic type of primary male...
