BreastArchives
The difference in contralateral breast cancer and ovarian cancer risks for BRCA1 founder variant (c.5266dup, c.4035del) carriers with primary breast cancer
Breast 4 min.
Recent research indicates that the risks of primary breast cancer (PBC) and ovarian cancer (OC) in BRCA1 pathogenic variant (PV) carriers may vary depending on the specific mutation`s location within the gene. However, current evidence remains insufficient to modify clinical decisions regarding...
Potential Loss of Imprinting of Tumor Suppressor Gene RB1 in Triple Negative Breast Cancer
Breast 6 min.
Triple-negative breast cancer (TNBC), which is characterized by the expression of estrogen receptor (ER-), progesterone receptor (PR-), and human epidermal growth factor receptor 2 (HER2-), is an aggressive subtype of breast cancer. Although it accounts for 15–20% of all breast cancer patients,...
Optimising breast cancer screening in national mammography screening centres: challenges and insights on implementing additional ultrasound for women with dense breast tissue — a qualitative study
Breast 7 min.
The public breast cancer screening programme in Germany is aimed at women aged 50–75 years; the upper age limit was raised from 69 to 75 in July 2024. Eligible women are invited to participate in the programme every two years. Some studies suggest that public mammography screening is associated...
Mammographic density and breast cancer pathological subtypes by menopausal status and body mass index
Breast 5 min.
Breast cancer (BC) is the most commonly diagnosed female tumor worldwide and in Europe [1]. In Spain, it is also the tumor with the highest incidence (representing 30.3% of all incident cases) and the leading cause of cancer death (14.7% of total cancer deaths) in women in 2022 [2]. As of December 2020,...
The role of NETosis in breast cancer: mechanistic insights and biomarker potential
Breast 12 min.
Breast cancer is the most prevalent malignancy among women worldwide and a leading cause of cancer-related morbidity and mortality. In 2020, approximately 2.3 million new cases were diagnosed, resulting in 685,000 deaths globally [1]. Incidence varies significantly across geographic regions and socioeconomic...
