SchizophreniaArchives
Resolving the heterogeneity of dopamine subsystems dysfunction in schizophrenia: a PET meta-analysis
Schizophrenia 6 min.
The “dopamine hypothesis” is one of the leading pathoetiologic theories of schizophrenia and has undergone significant evolution since its inception1, 2–3. The classical hypothesis was originally proposed in the mid-20th century following the discovery of antipsychotic drugs dopamine...
Depressive symptomatology in the first-episode schizophrenia spectrum disorders OPTiMiSE trial: prevalence, correlates, symptom progression and outcomes
Schizophrenia 6 min.
Schizophrenia has been conceptualised as non-affective psychosis since the first Kraepelinian dichotomous classification1,2, on which the international classifications of mental disorders have been based3. However, both manic and depressive symptoms appear to be intrinsic to schizophrenia4,5...
A study on Mahjong intervention to improve cognitive impairment in patients with schizophrenia: a pilot, single-blind, randomized, controlled trial
Schizophrenia 5 min.
Mental disorders remain one of the top ten global burdens, and schizophrenia has one of the highest measured years lived with disability among all diseases, injuries, and risk factors [1]. Cognitive deficits have long been considered a core symptom of schizophrenia and are significant factors leading...
Schizophrenia and sensory modulation problems: the relationship between severity, depression and sensory responsiveness
Schizophrenia 5 min.
The concept of sensory integration (SI), defined by Dr. Jean Ayres in the 1970s, refers to the ability to receive, process, organize, and respond to stimuli from one’s body and environment by generating appropriate neurological and behavioral reactions [1]. Sensory integration underlies sensory...
Decreased levels of platelet-derived growth factor subtypes and superoxide dismutase isoenzymes in early-onset schizophrenia
Schizophrenia 6 min.
Schizophrenia is a severe mental disorder with a global prevalence of approximately 1%. Symptom expression is highly heterogeneous, but core symptoms include disturbances in thought, perception, affect, and behavior that markedly interfere with education, social life, and career aspirations1. Early-onset...
