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Pharmacogenomic and inflammatory determinants of antipsychotic-induced extrapyramidal toxicity in Egyptian patients with schizophrenia
Schizophrenia
 1 min.

 Published on 28/04/2026 |  Original article (Full-text)  | Asmaa Mohamed Sayed Ahmed et al. | Expert opinion on drug metabolism & toxicology 2026; 22(3): 233-242

Extrapyramidal symptoms (EPS) are side effects of antipsychotic therapy, and genetic and inflammatory mechanisms may contribute to EPS risk. This study investigated the associations among ABCC2 (rs4148396) gene polymorphisms, serum interleukin-6 (IL-6) levels, and risperidone-induced EPS among patients...

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Robo2-Nrxn3 Deficiency: A Molecular Hub Linking Excitation-Inhibition Imbalance to the Pathogenesis of Schizophrenia
Schizophrenia
 1 min.

 Published on 21/04/2026 |  Original article (Full-text)  | Senqi Liu et al. | Schizophrenia bulletin. Volume 52(2).

Schizophrenia (SZ) is characterized by excitation-inhibition (E-I) imbalance as a core pathophysiological feature, but its molecular underpinnings remain elusive. Susceptibility gene Roundabout2 (Robo2), which regulates E-I balance in the central nervous system, may play a critical role in the pathogenesis...

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Plasma Fatty Acid Metabolites as Biomarkers of Metabolic Syndrome and Clinical Features in Chronic Schizophrenia
Schizophrenia
 1 min.

 Published on 14/04/2026 |  Original article (Full-text)  | Yeqing Dong et al. | Schizophrenia bulletin. Volume 52(2).

Metabolic syndrome (MetS) is a major risk factor for cardiovascular disease in schizophrenia (SCZ), yet its metabolic underpinnings, particularly in chronic SCZ, remain unclear. This study investigated plasma metabolic profiles and their associations with clinical features in chronic SCZ. Study Design:...

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Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia
Schizophrenia
 1 min.

 Published on 07/04/2026 |  Original article (Full-text)  | Ziyang Gao et al. | Cerebral Cortex. Volume 34(10).

Although aberrant static functional brain network activity has been reported in schizophrenia, little is known about how the dynamics of neural function are altered in first-episode schizophrenia and are modulated by antipsychotic treatment. The baseline resting-state functional magnetic resonance imaging...

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