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Three-dimensional analysis to predict recurrence of pure-solid non-small cell lung cancer after segmentectomy
Lung
 4 min.

 Published on 11/11/2025 |  Original article (Full-text)  | Tamura Masaya et al. | Journal of Cardiothoracic Surgery 2025; 20(1): 418

The Japan Clinical Oncology Group 0802 (JCOG 0802) recently conducted a pivotal randomized controlled trial [1] that compared the non-small cell lung cancer (NSCLC) survival rates of lobectomies and segmentectomies for tumors less than 2 cm in diameter. These findings highlighted the value of the segmentectomy...

Ivonescimab plus chemotherapy versus tislelizumab plus chemotherapy as first-line treatment for advanced squamous non-small-cell lung cancer (HARMONi-6): a randomised, double-blind, phase 3 trial
Lung
 1 min.

 Published on 04/11/2025 |  Original article (Full-text)  | Chen, Zhiwei et al. | The Lancet 2025; 406(10515): 2078-88

Squamous non-small-cell lung cancer (NSCLC) is associated with worse clinical outcomes than non-squamous NSCLC, but treatment options are scarce. We aimed to evaluate the efficacy and safety of ivonescimab plus chemotherapy versus tislelizumab plus chemotherapy as a first-line therapy for patients with...

Efficacy and safety of limertinib versus gefitinib as first-line treatment for locally advanced or metastatic non-small-cell lung cancer with EGFR-sensitising mutation: a randomised, double-blind, double-dummy, phase 3 trial
Lung
 1 min.

 Published on 28/10/2025 |  Original article (Full-text)  | Shi, Yuankai et al. | The Lancet Respiratory Medicine 2025; 13(8): 677-86

Limertinib is a new third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. This study aimed to prospectively assess the efficacy and safety of limertinib versus gefitinib as a first-line treatment for locally advanced or metastatic non-small-cell lung cancer (NSCLC) with...

The lung immune prognostic index stratifies the occurrence of checkpoint inhibitor pneumonitis in advanced non-small cell lung cancer patients: a multi-institutional cohort study
Lung
 4 min.

 Published on 21/10/2025 |  Original article (Full-text)  | Gong Bingxin et al. | British Journal of Cancer 2025; 133(8): 1152-61

Advanced non-small-cell lung cancer (NSCLC) is a formidable malignancy associated with a poor prognostic outlook, typically manifesting with notably low 1-year and 5-year overall survival rates [1]. Advanced NSCLC often loses the opportunity for curative surgery at the time of diagnosis [2]. Recently,...