LungArchives
Molecular characteristics and responses to EGFR tyrosine kinase inhibitors in non-small cell lung cancer patients with EGFR exon 19 insertions
Lung 5 min.
The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have demonstrated profound clinical efficacies in non-small cell lung cancer (NSCLC) patients with EGFR exon 19 deletion (19del) or L858R mutations, showing superior survival benefit over platinum-based chemotherapy...
Results from a phase Ib study of telisotuzumab vedotin in combination with osimertinib in patients with c-Met protein-overexpressing, EGFR-mutated locally advanced/metastatic non-small-cell lung cancer (NSCLC) after progression on prior osimertinib
Lung 1 min.
Osimertinib is the standard first-line treatment for advanced epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). However, treatment resistance is inevitable and increased c-Met protein expression correlates with resistance. Telisotuzumab vedotin (Teliso-V) is an antibody–drug...
Machine learning in prediction of epidermal growth factor receptor status in non-small cell lung cancer brain metastases: a systematic review and meta-analysis
Lung 5 min.
Lung cancer (LC) stands as a principal cause of cancer-related death and is responsible for approximately 1.18 million annual deaths worldwide [1, 2]. Lung cancer brain metastases (LCBM) are a frequent complication in individuals with lung cancer, accounting for 10–36% of cases and comprising...
Genomic and clinical characterization of HER2 exon 20 mutations in non-small cell lung cancer: insights from a multicenter study in South China
Lung 5 min.
Lung cancer remains a significant global health issue, with non-small cell lung cancer (NSCLC) accounting for 80-85% of cases [1, 2]. Early detection of NSCLC is often hindered by its asymptomatic nature, leading to diagnoses at advanced stages, missed treatment opportunities, and poor prognosis [3,...
Nomogram model for the preoperative prediction of spread through air spaces in sub-centimeter non-small cell lung cancer
Lung 5 min.
Lung cancer is still the malignant tumor with the greatest incidence and death rate in China, and its occurrence is rising annually around the world [1, 2]. Recent years have seen an increase in the diagnosis rate of early lung cancer, including sub-centimeter lung cancer, thanks to the widespread use...
