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Cost-effectiveness analysis of intensity modulated radiation therapy versus robot-assisted radical prostatectomy for patients with low-risk prostate cancer in Japan

 Published on 17/04/2026 |  Original article (Full-text)  | Ataru Igarashi et al. | Journal of Radiation Research. Volume 67(2).

This study evaluated the cost-effectiveness of hypofractionated intensity-modulated radiation therapy delivered in 20 fractions (IMRT-20) compared with robot-assisted radical prostatectomy (RARP) for patients with localized low-risk prostate cancer in Japan. A state-transition Markov model was developed...

Elucidating Cellular Senescence-related Genes in Benign Prostatic Hyperplasia Through Mendelian Randomization and Single-cell RNA Sequencing

 Published on 10/04/2026 |  Original article (Full-text)  | Yichuan Wang et al. | The journals of gerontology. Series A. Volume 80(7).

Benign prostatic hyperplasia (BPH) is a widely observed disorder in older men, with substantial evidence indicating that cellular senescence serves a pivotal function in its progression. This investigation seeks to pinpoint cellular senescence-related genes causally connected with BPH and to examine...

Ultra low pressure robotic assisted radical prostatectomy (RARP) with pelvic lymph node dissection performed as a day case: first reported case in the UK

 Published on 03/04/2026 |  Original article (Full-text)  | Mayas Rddah et al. | Journal of surgical case reports. Volume 2026(1).

A man in his sixties with locally advanced prostate cancer underwent ultra-low pressure robotic-assisted radical prostatectomy (RARP) with pelvic lymph node dissection (PLND) and was safely discharged the same day. This is the first reported UK case of day-case RARP with PLND performed at 6 mmHg. The...

Trends in net survival for prostate cancer in Japan, 2000-14 (CONCORD-3)

 Published on 27/03/2026 |  Original article (Full-text)  | Rina Tanaka et al. | Japanese Journal of Clinical Oncology. Volume 56(Supplement 1).

We aimed at assessing 15-year trends in 5-year net survival for men diagnosed with prostate cancer during 2000-2014 and registered by 16 Japanese regional population-based cancer registries included in the CONCORD-3 study. Methods: We included data on adult men (15-99 years) diagnosed with prostate cancer...

Hyaluronan stimulates transformation of androgen-independent prostate cancer

 Published on 20/03/2026 |  Original article (Full-text)  | Shi-Lung Lin et al. | Carcinogenesis. Volume 28(2).

Interaction between extracellular matrices and cancer cell receptors frequently alters signal transduction pathways, leading to malignant transformation and metastasis. Hyaluronan (HA) is a tumor promoter and enhancer in transformation of androgen-independent (AI) prostate cancer (CaP); however, the...