
Interaction between extracellular matrices and cancer cell receptors frequently alters signal transduction pathways, leading to malignant transformation and metastasis. Hyaluronan (HA) is a tumor promoter and enhancer in transformation of androgen-independent (AI) prostate cancer (CaP); however, the...

Prostate cancer (PCa) is the most common solid organ malignancy among men in developed countries and represents one of the leading causes of cancer-related mortality worldwide [1, 2]. Radical prostatectomy (RP) remains the standard surgical treatment for localized and locally advanced PCa [1]. In recent...

Prostate cancer (PCa) is one of the most common malignancies in men worldwide and poses a significant threat to male health [1]. According to the World Health Organization, PCa ranks second in the incidence of newly diagnosed cancers among men globally [2]. In Asia, particularly in China, although the...

Prostate cancer (PCa) is among the most common malignancies in men. With the widespread adoption of prostate-specific antigen (PSA) screening, detection rates have steadily increased [1]. Radical prostatectomy (RP) remains a first-line treatment for patients with localized or locally advanced disease;...

Prostate cancer is the second most prevalent malignancy globally and the fifth leading cause of cancer-related mortality in males [1].Researchers have extensively investigated factors influencing cancer mortality to develop more effective intervention strategies. A substantial proportion of PCa patients...