Prostate Cancer & BPHArchives
Novel biomarkers driving treatment selection in metastatic castration-sensitive prostate cancer: fundamentals of personalized clinical decision making
Prostate Cancer & BPH 1 min.
Prostate cancer is well known to be androgen-dependent, with growth directly relying on the androgen receptor signaling pathway. In fact, androgen deprivation therapy, with or without Docetaxel and/or newer hormonal drugs such as Abiraterone acetate, Enzalutamide, Apalutamide, and Darolutamide, remains...
Fusion genes in precision oncology: prostate cancer as a diagnostic case study
Prostate Cancer & BPH 1 min.
Fusion genes represent one of the most specific molecular alterations in human cancer and have long served as important diagnostic and therapeutic biomarkers. Advances in next-generation sequencing have driven a rapid expansion in fusion gene discovery. Clinical translation has lagged however, particularly...
Drinking water nitrate, disinfection byproducts, and prostate cancer incidence in the Agricultural Health Study
Prostate Cancer & BPH 1 min.
Drinking water can be an important source of exposure to nitrate and disinfection by-products, including trihalomethanes (THMs) and haloacetic acids (HAAs). N-nitroso compounds formed endogenously after nitrate ingestion are animal carcinogens, and THM and HAA exposures increase the risk of some cancers....
Long-term performance of the Gleason score in predicting metastatic and fatal prostate cancer
Prostate Cancer & BPH 1 min.
The time dependence in the performance of prognostic factors for cancer survival is typically incompletely understood, including in prostate cancer. We applied a "cumulative/dynamic" time-varying area under the curve (tAUC) for cumulative incidence of lethal prostate cancer (metastases/cancer-specific...
Guideline-based physical activity and health-related quality of life among prostate cancer survivors: a target trial emulation in the Health Professionals Follow-up Study
Prostate Cancer & BPH 1 min.
Prostate cancer and its treatment can impact health-related quality of life. Evidence for physical activity strategies sustained over long periods to improve quality of life is limited. Given the limited feasibility of a randomized trial to answer this question, we emulated a target trial of physical...
