Blood CancerArchives
B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape
Blood Cancer 7 min.
Multiple myeloma (MM) is a plasma cell malignancy characterized by the abnormal accumulation of plasma cells primarily in the bone marrow (BM) [1]. This hematological malignancy is still considered incurable, mainly due to cellular heterogeneity and the development of therapy resistance. Recent advances...
WTAP promotes the proliferation of multiple myeloma by regulating the hippo pathway through m6A modification of MAP6D1
Blood Cancer 1 min.
Multiple myeloma (MM) remains incurable, largely owing to the lack of effective therapeutic targets. Wilms' tumor 1-associated protein (WTAP) has been implicated in MM tumorigenesis, but its underlying molecular mechanisms remain unclear. This study aimed to elucidate the role of WTAP in MM progression....
Supporting treatment decision-making for patients with multiple myeloma post-DRd in Italy: a multi-criteria decision framework
Blood Cancer 6 min.
Multiple Myeloma (MM) is a rare hematological tumor affecting B lymphocytes and is the second-most commonly diagnosed hematological malignancy in Europe [1]. In Italy, MM accounts for 1.5% of all diagnosed tumors, with an annual incidence of approximately 5,700 cases [2] and a median age at diagnosis...
Tandem autologous hematopoietic stem cell transplantation in multiple myeloma: A historical perspective and current challenges
Blood Cancer 9 min.
Multiple myeloma (MM) is a malignant hematologic disorder characterized by the abnormal proliferation of clonal plasma cells, accounting for approximately 10% of hematologic malignancies and 1% of all cancers [1]. Despite significant therapeutic progress in recent years, MM remains incurable and exhibits...
Proceedings of the 4th European Congress controversies in Leukemias, held in Brussels, Belgium, 20-21 November, 2023.
Blood Cancer 1 min.
AML Classifications: WHO vs ICC 2022 Update The following is a summary of the article “Definitions of Acute Myeloid Leukaemia and their clinical significance according to the WHO 2022 and ICC classification” by Donata Backhaus et al (University of Leipzig Medical Center, Germany), which...
