Blood CancerArchives
Evolving treatments and outcomes in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a real-world study in China
Blood Cancer 6 min.
Multiple myeloma (MM) is an incurable plasma cell neoplasm [1]. However, the introduction of autologous stem cell transplantation (ASCT), proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs), and monoclonal antibodies has significantly advanced its management. ASCT, which includes a sequence of...
Lacrimal Sac Chronic Lymphocytic Leukemia: A Review of Clinical Features, Investigations, and Management.
Blood Cancer 1 min.
This study reviews all reported cases of lacrimal gland chronic lymphocytic leukemia (CLL) to identify patterns in clinical presentation, diagnosis, and management to aid in early recognition and treatment of this uncommon occurrence. Methods: A comprehensive search of medical literature databases was...
CD9, a tetraspanin in cancer: biology and therapeutic promise in acute leukemia
Blood Cancer 10 min.
Tetraspanins (TSPANs), a family of transmembrane proteins, play a central role in mediating interactions between cancer cells and microenvironment by contributing to the organization of the cellular membranes. Among them, TSPAN29, also known as cluster of differentiation 9 (CD9), interacts with specific...
Emerging strategies in CAR-T cell therapy for acute myeloid leukemia: overcoming heterogeneity and improving safety through dual-antigen targeting
Blood Cancer 10 min.
Acute myeloid leukemia (AML) is a highly aggressive and heterogeneous hematological malignancy of the bone marrow that has an annual incidence of 4.3 per 100,000 in the United States, increasing with age [1]. Accounting for about 80% of cases, AML is the most frequent type of acute leukemia in adults...
Genetic insights into acute lymphoblastic leukemia: the role of MDR1 and IL18 polymorphisms in Egyptian children
Blood Cancer 6 min.
Acute lymphoblastic leukemia (ALL) is a particularly aggressive form of hematopoietic cancer that is both physiologically diverse and clinically aggressive. The clonal proliferation and accumulation of immature lymphoid progenitor cells are the causes of this condition, which ultimately results in extensive...
