Blood CancerArchives
Hepatitis E virus infections in people with multiple myeloma: an emerging challenge in the era of immunotherapeutic approaches
Blood Cancer 1 min.
Hepatitis E virus (HEV) is an under-recognized cause of viral hepatitis, with rising incidence in high-income countries largely driven by zoonotic transmission. Patients with multiple myeloma (MM) are especially vulnerable to HEV, yet there have been no recommendations for antiviral treatment or on its...
Ramantamig (JNJ-79635322), a novel T-cell-engaging trispecific antibody targeting BCMA, GPRC5D, and CD3, in multiple myeloma models
Blood Cancer 1 min.
In multiple myeloma (MM), cell-specific antigens are valuable targets for developing effective T-cell-engaging therapeutics that can provide good immune responses. Achieving a sustained immune response in recurrent MM, however, remains challenging. Ramantamig (JNJ-79635322) is a trispecific antibody...
Linvoseltamab, a BCMA-directed CD3 T-cell engager for multiple myeloma: a patient-centric option via a response-adapted dosing regimen
Blood Cancer 1 min.
Despite advances in the treatment of multiple myeloma (MM), there remains a significant need for new modalities, mechanisms of action (MOA), and combinations to achieve durable remissions. Bispecific T-cell engagers (BiTEs), particularly those targeting B-cell maturation antigen (BCMA), have demonstrated...
Treatment Outcomes and Factors Affecting Survival in Pediatric Acute Myeloid Leukemia
Blood Cancer 5 min.
In recent years, survival rate of pediatric acute myeloid leukemia (AML) has increased to as high as 70–80% [1, 2]. Mortality rates have declined with the development of induction chemotherapy blocks and supportive care [3, 4, 5, 6–7]. Improvements in conditioning regimens for hematopoietic...
Hypermethylation-mediated silencing of RASD1 drives multiple myeloma pathogenesis
Blood Cancer 2 min.
Multiple myeloma (MM) is a malignant neoplasm of clonal plasma cells and represents the second most common hematological malignancy [1]. Despite therapeutic advances, including the introduction of novel agents and stem cell transplantation, MM remains largely incurable due to the inevitable development...
