Blood CancerArchives
Promising Drugs Targeting Specific Mechanisms of Deregulation in T Cell Lineage Acute Lymphoblastic Leukemia
Blood Cancer 4 min.
T cell lineage acute lymphoblastic leukemia (ALL) is characterized by immunophenotypic and molecular high diversity. T-ALL represents 15% of pediatric and 25% of adult newly diagnosed ALL cases [1]. In frontline therapy, all patients with T-ALL are treated with similar multiagent chemotherapy regimens...
Analysis of hemolysis-associated acute myeloid leukemia genes obtained using weighted gene co-expression network analysis and a Mendelian randomization study
Blood Cancer 4 min.
Acute myeloid leukemia (AML) is preceded by malignant clonal expansion of progenitor cells with impaired differentiation and is associated with the highest proportion of deaths among all types of leukemia [1, 2, 3–4]. In the United States, in 2024, there were 20,800 new cases of AML, accounting...
Response to daratumumab-retreatment in patients with multiple myeloma
Blood Cancer 4 min.
Multiple myeloma (MM) is a malignant hematologic neoplasia characterized by bone marrow infiltration of monoclonal plasma cells. The secreted functionless monoclonal immunoglobulins or light chains can be detected as the M-protein and clonally increased light chains in serum and/or urine [1, 2]. MM remains...
Daratumumab/Bortezomib/Thalidomide/Dexamethasone in Newly Diagnosed Myeloma: CASSIOPEIA Minimal Residual Disease Results
Blood Cancer 1 min.
Previous results from CASSIOPEIA (NCT02541383) demonstrated superior progression-free survival (PFS) and minimal residual disease (MRD) negativity with the addition of daratumumab to bortezomib, thalidomide, and dexamethasone (VTd) induction/consolidation and with daratumumab maintenance versus observation...
Proceedings of the 4th European Congress controversies in Leukemias, held in Brussels, Belgium, 20-21 November, 2023.
Blood Cancer 1 min.
AML Classifications: WHO vs ICC 2022 Update The following is a summary of the article “Definitions of Acute Myeloid Leukaemia and their clinical significance according to the WHO 2022 and ICC classification” by Donata Backhaus et al (University of Leipzig Medical Center, Germany), which...
