Blood CancerArchives
Exploring secondary extramedullary myeloma disease: a five-predictor scoring system with spotlight on double-hit cytogenetics
Blood Cancer 7 min.
Multiple myeloma (MM), a malignancy characterized by the proliferation of aberrant plasma cells closely interacting with the bone marrow milieu, has seen considerable advancements in overall survival (OS) over the last 15 years [1]. However, MM remains predominantly incurable, with most patients...
Therapy related acute myeloid leukemia secondary to CAR-T therapy in refractory/relapsed multiple myeloma patient showing poor prognosis
Blood Cancer 2 min.
Chimeric antigen receptor T-cell (CAR-T) immunotherapy has been widely adopted as a promising strategy for the treatment of hematological malignancies (HMs), as well as other solid tumors and autoimmune diseases [1]. Notably, its efficacy in the treatment of HMs especially including B-cell lymphoma,...
Promising Drugs Targeting Specific Mechanisms of Deregulation in T Cell Lineage Acute Lymphoblastic Leukemia
Blood Cancer 4 min.
T cell lineage acute lymphoblastic leukemia (ALL) is characterized by immunophenotypic and molecular high diversity. T-ALL represents 15% of pediatric and 25% of adult newly diagnosed ALL cases [1]. In frontline therapy, all patients with T-ALL are treated with similar multiagent chemotherapy regimens...
Analysis of hemolysis-associated acute myeloid leukemia genes obtained using weighted gene co-expression network analysis and a Mendelian randomization study
Blood Cancer 4 min.
Acute myeloid leukemia (AML) is preceded by malignant clonal expansion of progenitor cells with impaired differentiation and is associated with the highest proportion of deaths among all types of leukemia [1, 2, 3–4]. In the United States, in 2024, there were 20,800 new cases of AML, accounting...
Proceedings of the 4th European Congress controversies in Leukemias, held in Brussels, Belgium, 20-21 November, 2023.
Blood Cancer 1 min.
AML Classifications: WHO vs ICC 2022 Update The following is a summary of the article “Definitions of Acute Myeloid Leukaemia and their clinical significance according to the WHO 2022 and ICC classification” by Donata Backhaus et al (University of Leipzig Medical Center, Germany), which...
