Log in  First Connection?
  
EnglishJapaneseFrenchSpanishGerman

Colorectal: Archives News of the month

5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complex
Colorectal
 1 min.

 Published on 28/07/2026 |  Original article (Abstract)  | Subarno Paul et al. | Expert Opinion on Therapeutic Targets 2026; 30(7): 785-802

Previous study showed the PARP inhibitor ABT-888 potentiates the cytotoxicity of 5-fluorouracil (5-FU) by inhibiting PARP1-mediated mismatch repair (MMR) pathway via MSH6 deregulation in MMR-proficient colorectal cancer stem cells (CRC-CSCs). Emerging evidence indicates 5-FU regulates O -methylguanine-DNA-methyltrans...

Abstract Order article

Tumour-Associated Neutrophils in Colorectal Cancer: a Systematic Review, Meta-analysis, and Comprehensive Literature Review
Colorectal
 1 min.

 Published on 21/07/2026 |  Original article (Abstract)  | Abrahao, Ana Beatriz Kinupe et al. | Journal of Gastrointestinal Cancer. Volume 57(1).

Neutrophils are at the forefront of innate immune response. The prognostic impact of tumour-associated neutrophils (TANs) remains unclear. This study aimed to evaluate the prognostic role of TANs in colorectal cancer (CRC). Methods: A systematic review and meta-analysis were conducted using PubMed, Embase,...

Abstract Order article

Validation of the fear of cancer recurrence inventory-short form in long-term colorectal cancer survivors
Colorectal
 1 min.

 Published on 14/07/2026 |  Original article (Abstract)  | Ingeman, Katrine et al. | Journal of Patient-Reported Outcomes. Volume 10(1).

The Fear of Cancer Recurrence Inventory-Short Form (FCRI-SF) is commonly used to categorize the severity of fear of cancer recurrence (FCR) defined as fear, worry, or concern about cancer returning or progressing. Evaluating the FCRI-SF factor structure and the clinical cut-off score in specific cancer...

Abstract Order article

Fungi and colorectal cancer: from dysregulation to clinical translation
Colorectal
 1 min.

 Published on 07/07/2026 |  Original article (Abstract)  | Yinhang, Wu et al. | Gut Pathogens. Volume 18(1).

Research on the gut microbiota has primarily focused on bacterial communities. However, the role of fungi-the second-largest eukaryotic component of the gut microbiome-in the development and progression of colorectal cancer (CRC) has been less extensively studied compared to bacteria. Recent studies...

Abstract Order article

Lipid metabolism as a central driver of immune remodeling and therapeutic vulnerability in metastatic colorectal cancer
Colorectal
 1 min.

 Published on 30/06/2026 |  Original article (Abstract)  | Shang, Yuru et al. | Lipids in Health and Disease. Volume 25(1).

Dysregulated lipid metabolism has emerged as a defining hallmark of colorectal cancer (CRC) progression, particularly in metastatic disease, where metabolic adaptation and immune evasion are tightly interconnected, as demonstrated in both murine models and human studies. Increasing evidence has demonstrated...

Abstract Order article