ColorectalArchives
Fungi and colorectal cancer: from dysregulation to clinical translation
Colorectal 1 min.
Research on the gut microbiota has primarily focused on bacterial communities. However, the role of fungi-the second-largest eukaryotic component of the gut microbiome-in the development and progression of colorectal cancer (CRC) has been less extensively studied compared to bacteria. Recent studies...
Lipid metabolism as a central driver of immune remodeling and therapeutic vulnerability in metastatic colorectal cancer
Colorectal 1 min.
Dysregulated lipid metabolism has emerged as a defining hallmark of colorectal cancer (CRC) progression, particularly in metastatic disease, where metabolic adaptation and immune evasion are tightly interconnected, as demonstrated in both murine models and human studies. Increasing evidence has demonstrated...
Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling
Colorectal 1 min.
Cancer cells exhibit abnormal dependence on glutamine, which is associated with the hyperactivation of γ-aminobutyric acid (GABA) metabolic pathways that promotes tumor growth. The α2-adrenergic receptor agonist dexmedetomidine (DEX) has been reported to promote colorectal cancers (CRC) progression....
Integrating histopathology and immune marker analysis for machine learning-based colorectal cancer prognostics
Colorectal 1 min.
This study aims to create a machine-learning framework that integrates histopathological imaging, immune marker data, and clinical features to classify tumor types, determine histological grades, and predict survival outcomes in CRC patients. Materials and methods: This study analyzed 650 CRC cases,...
Sacituzumab govitecan in colorectal cancer: clinical evidence and future directions
Colorectal 1 min.
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide and continues to pose a significant global health burden. Despite therapeutic advances, the prognosis remains poor due to limited treatment options, resistance to therapy, and frequent metastasis. Standard treatment...
