ColorectalArchives
The novel role of DUSP4 in suppressing ferroptosis and promoting cytotoxicity of CD8+ T cells in MSI colorectal cancer
Colorectal 8 min.
Colorectal cancer (CRC) ranks as the second leading cause of cancer death in the world [1]. As a heterogeneous disease, one of the major carcinogenetic pathways of CRC is microsatellite instability (MSI) [2]. MSI CRC is a subtype of cancer that is characterised by the presence of a defective DNA mismatch...
The single-cell atlas of colorectal cancer reveals cellular heterogeneity and key molecular features of the tumor immune microenvironment
Colorectal 9 min.
Colorectal cancer (CRC) is one of the most common and deadly malignancies worldwide, with its incidence increasing with age [1]. Although traditional treatments like surgery and chemotherapy have had some success, many patients still face poor prognosis due to disease recurrence and metastasis [2]. In...
Importance of PERK pathway modulation on colorectal cancer management: a systematic review
Colorectal 5 min.
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide [1]. Surgery is the primary treatment approach, and chemotherapy in combination with radiation therapy is often used for advanced CRC. Despite significant advances in these treatment...
Comprehensive evaluation and progress of colorectal cancer screening methods
Colorectal 7 min.
According to statistics from the International Agency for Research on Cancer (IARC) GLOBOCAN program, CRC is the third most common Malignancy and the second leading cause of Malignancy-related deaths worldwide in 2022. According to the data, it is estimated that there will be more than 1.9 million...
Integrating COX-2, stromal PD-L1, and T-cell infiltration enhances prognostic stratification in colorectal cancer
Colorectal 7 min.
Chronic inflammation, sustained by an imbalance of pro- and anti-inflammatory molecules, including lipid mediators, supports the initiation and progression of colorectal cancer (CRC)-the third most commonly diagnosed and second deadliest malignancy worldwide [1, 2–3]. Among the implicated lipid...
