ColorectalArchives
New strategies to enhance the efficacy of PD-1/PD-L1 inhibitors in treating microsatellite stable colorectal cancer
Colorectal 1 min.
Immune checkpoint therapy has demonstrated significant potential in the treatment of various solid tumors. Among these, tumor-induced immunosuppression mediated by programmed cell death protein 1 (PD-1) represents a critical checkpoint. PD-1/programmed death-ligand 1 (PD-L1) inhibitors have been proven...
Coagulation markers as independent predictors of colorectal cancer aggressiveness
Colorectal 4 min.
Colorectal cancer (CRC), encompassing both colon and or rectal cancer, is a major health concern ranking as the third most commonly diagnosed and second most deadly cancer globally [1]. In 2020, CRC accounted for 9.4% of all cancer-related deaths [2]. With an increasing incidence particularly among elderly...
Helicobacter pylori, peptic ulcer disease, and colorectal cancer: a prospective study with genome-wide interaction analysis and Mendelian randomization
Colorectal 5 min.
Colorectal cancer (CRC) represents one of the most prevalent malignancies worldwide, ranking as the third most commonly diagnosed cancer and the second leading cause of cancer-related mortality globally [1]. Its pathogenesis involves a complex interplay of genetic predisposition, environmental factors,...
Association between GLP-1 receptor agonists as a class and colorectal cancer risk: a meta-analysis of retrospective cohort studies
Colorectal 5 min.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are extensively used in the management of patients with type 2 diabetes mellitus (T2DM) and obesity [1]. These agents also maintain weight and cardiovascular health, along with glycemic control, to reduce long-term complications and improve the quality...
TRIM26 deficiency potentially suppresses colorectal cancer liver metastasis through NF-κB-mediated M1-like tumor-associated macrophage polarization
Colorectal 6 min.
Colorectal cancer (CRC) is the third leading cause of cancer-related mortality globally, and its incidence has been increasing year by year, posing a major threat to human health [1, 2, 3–4]. The development of CRC is often accompanied by metastasis, with the liver being the most common metastatic...
