Log in  First Connection?
  
EnglishJapaneseFrenchSpanishGerman

ColorectalArchives

5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complex
Colorectal
 1 min.

 Published on 28/07/2026 |  Original article (Full-text)  | Subarno Paul et al. | Expert Opinion on Therapeutic Targets 2026; 30(7): 785-802

Previous study showed the PARP inhibitor ABT-888 potentiates the cytotoxicity of 5-fluorouracil (5-FU) by inhibiting PARP1-mediated mismatch repair (MMR) pathway via MSH6 deregulation in MMR-proficient colorectal cancer stem cells (CRC-CSCs). Emerging evidence indicates 5-FU regulates O -methylguanine-DNA-methyltrans...

HTML version PDF version  Print abstract

Tumour-Associated Neutrophils in Colorectal Cancer: a Systematic Review, Meta-analysis, and Comprehensive Literature Review
Colorectal
 1 min.

 Published on 21/07/2026 |  Original article (Full-text)  | Abrahao, Ana Beatriz Kinupe et al. | Journal of Gastrointestinal Cancer. Volume 57(1).

Neutrophils are at the forefront of innate immune response. The prognostic impact of tumour-associated neutrophils (TANs) remains unclear. This study aimed to evaluate the prognostic role of TANs in colorectal cancer (CRC). Methods: A systematic review and meta-analysis were conducted using PubMed, Embase,...

HTML version PDF version  Print abstract

Validation of the fear of cancer recurrence inventory-short form in long-term colorectal cancer survivors
Colorectal
 1 min.

 Published on 14/07/2026 |  Original article (Full-text)  | Ingeman, Katrine et al. | Journal of Patient-Reported Outcomes. Volume 10(1).

The Fear of Cancer Recurrence Inventory-Short Form (FCRI-SF) is commonly used to categorize the severity of fear of cancer recurrence (FCR) defined as fear, worry, or concern about cancer returning or progressing. Evaluating the FCRI-SF factor structure and the clinical cut-off score in specific cancer...

HTML version PDF version  Print abstract

Fungi and colorectal cancer: from dysregulation to clinical translation
Colorectal
 1 min.

 Published on 07/07/2026 |  Original article (Full-text)  | Yinhang, Wu et al. | Gut Pathogens. Volume 18(1).

Research on the gut microbiota has primarily focused on bacterial communities. However, the role of fungi-the second-largest eukaryotic component of the gut microbiome-in the development and progression of colorectal cancer (CRC) has been less extensively studied compared to bacteria. Recent studies...

HTML version PDF version  Print abstract