ColorectalArchives
5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complex
Colorectal 1 min.
Colorectal
1 min.
Published on 28/07/2026 |
Original article (Full-text)
| Subarno
Paul
et al. | Expert Opinion on Therapeutic Targets 2026; 30(7): 785-802
Previous study showed the PARP inhibitor ABT-888 potentiates the cytotoxicity of 5-fluorouracil (5-FU) by inhibiting PARP1-mediated mismatch repair (MMR) pathway via MSH6 deregulation in MMR-proficient colorectal cancer stem cells (CRC-CSCs). Emerging evidence indicates 5-FU regulates O -methylguanine-DNA-methyltrans...
Tumour-Associated Neutrophils in Colorectal Cancer: a Systematic Review, Meta-analysis, and Comprehensive Literature Review
Colorectal 1 min.
Colorectal
1 min.
Published on 21/07/2026 |
Original article (Full-text)
| Abrahao, Ana Beatriz Kinupe et al. | Journal of Gastrointestinal Cancer. Volume 57(1).
Neutrophils are at the forefront of innate immune response. The prognostic impact of tumour-associated neutrophils (TANs) remains unclear. This study aimed to evaluate the prognostic role of TANs in colorectal cancer (CRC). Methods: A systematic review and meta-analysis were conducted using PubMed, Embase,...
