ColorectalArchives
An in-frame deletion mutation in MLH1 drives Lynch syndrome-associated colorectal cancer
Colorectal 4 min.
Hereditary cancer syndromes are commonly characterized by notably increased lifetime susceptibilities to multiple cancers, frequently manifesting at a young age [1]. The identification and detection of individuals with specific inherited predispositions to cancer have profound implications for both patients...
Genetic mechanism of β-alanine metabolic pathway affecting colorectal cancer prognosis
Colorectal 6 min.
It is estimated that by 2022, approximately 4.82 million new instances of cancer and 3.21 million fatalities due to cancer will occur in China. Colorectal cancer (CRC) accounts for 12.3% of the total cancer incidence and 9.6% of the cancer-related deaths [1, 2]. The incidence and mortality rates of CRC,...
Tertiary lymphoid structures in the microenvironment of colorectal cancer: exploring new therapeutic targets
Colorectal 6 min.
According to the latest global cancer statistics report, colorectal cancer (CRC) maintains a significant burden worldwide, ranking as the third most commonly diagnosed cancer with 1.92 million new cases and the second leading cause of cancer-related mortality with 0.9 million deaths [1]. This epidemiological...
Lysine acetyltransferase KAT2A modulates ferroptosis during colorectal cancer development
Colorectal 1 min.
Histone modifications, especially the lysine acetylation, have drawn increasing attention in cancer research area. The aim of this research is to explore the molecular mechanisms underlying the regulation of lysine acetyltransferase 2 A (KAT2A) on colorectal cancer (CRC). Clinical samples were...
