ColorectalArchives
Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling
Colorectal 1 min.
Cancer cells exhibit abnormal dependence on glutamine, which is associated with the hyperactivation of γ-aminobutyric acid (GABA) metabolic pathways that promotes tumor growth. The α2-adrenergic receptor agonist dexmedetomidine (DEX) has been reported to promote colorectal cancers (CRC) progression....
Integrating histopathology and immune marker analysis for machine learning-based colorectal cancer prognostics
Colorectal 1 min.
This study aims to create a machine-learning framework that integrates histopathological imaging, immune marker data, and clinical features to classify tumor types, determine histological grades, and predict survival outcomes in CRC patients. Materials and methods: This study analyzed 650 CRC cases,...
Sacituzumab govitecan in colorectal cancer: clinical evidence and future directions
Colorectal 1 min.
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide and continues to pose a significant global health burden. Despite therapeutic advances, the prognosis remains poor due to limited treatment options, resistance to therapy, and frequent metastasis. Standard treatment...
Safety of fruquintinib mono- and combo therapy in metastatic colorectal cancer: real-world subgroup analysis from China
Colorectal 1 min.
Fruquintinib, a highly selective vascular endothelial growth factor receptor 1, 2, 3 inhibitors, has demonstrated significant efficacy in phase III trials for metastatic colorectal cancer (mCRC). However, real-world evidence is essential to confirm its safety profile across diverse treatment settings....
Antitumor activity of silver (Ag) complexes in colorectal cancer cells by oxidative stress and apoptosis induction
Colorectal 1 min.
Metal-based drugs, such as the platinum-derived compounds cisplatin and oxaliplatin, are routinely used in cancer therapy. Currently, among these, only oxaliplatin has demonstrated significant efficacy in colorectal cancer (CRC). This urges the necessity of developing more effective anticancer agents....
