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Alzheimer's Disease: Archives News of the month

Preclinical Alzheimer Disease pathology in studies of memory and aging

 Published on 02/04/2025 |  Original article (Abstract)  | Nicole S. McKay et al. | Alzheimer's & dementia : the journal of the Alzheimer's Association 2024; 20(S2): 093516

Aryloxypropanolamine mitigates Alzheimer‐like phenotype by directly removing amyloid aggregates

 Published on 26/03/2025 |  Original article (Abstract)  | Soljee Yoon et al. | Alzheimer's & dementia : the journal of the Alzheimer's Association 2024; 20(S6): 088498

The accumulation of amyloidogenic proteins is recognized as a primary biomarker, initiator of pathology, and a potential therapeutic target for Alzheimer’s disease (AD). An unbiased screening of a small molecule library was conducted to identify new chemical compounds exhibiting amyloid‐dissociative...

Preclinical Alzheimer Disease pathology in studies of memory and aging

 Published on 19/03/2025 |  Original article (Abstract)  | Nicole S. McKay et al. | Alzheimer's & dementia : the journal of the Alzheimer's Association 2024; 20(S9): 094151

Pragmatic considerations in clinical biomarker testing for Alzheimer disease

 Published on 12/03/2025 |  Original article (Abstract)  | Suzanne E. Schindler et al. | Alzheimer's & dementia : the journal of the Alzheimer's Association 2024; 20(S2): 088362

Development of tau targeted protein degraders for Alzheimer disease

 Published on 05/03/2025 |  Original article (Abstract)  | Lisha Wang et al. | Alzheimer's & dementia : the journal of the Alzheimer's Association 2024; 20(S6): 086380

Alzheimer disease (AD) is a progressive neurodegenerative disease that is accountable for the leading case of dementia in elder people. Before, only symptomatic treatments are available for AD. Since 2021, two anti‐amyloid antibodies aducanumab and lecanemab have been approved by the US Food and...