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Lymphoma: Archives News of the month

A rare case of splenic marginal zone lymphoma with MYD88 mutation transformed into diffuse large B-cell lymphoma: case report and literature review
Lymphoma
 3 min.

 Published on 08/04/2025 |  Original article (Abstract)  | Chen Yuzhan et al. | Annals of Hematology 2025; 104(2): 1269-74

Splenic marginal zone lymphoma (SMZL) is an indolent small B-cell tumour originating from the marginal zone of the spleen. It affects the spleen, bone marrow, and peripheral blood and accounts for 2% of all non-Hodgkin lymphomas [1]. Clinically, SMZL primarily presents as splenomegaly, and a diagnosis...

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Enrichment of CD7+CXCR3+ CAR T cells in infusion products is associated with durable remission in relapsed or refractory diffuse large B-cell lymphoma
Lymphoma
 1 min.

 Published on 01/04/2025 |  Original article (Abstract)  | Bartolini, R. et al. | Annals of Oncology 2025; AOP:10.1016/j.annonc.2025.03.011

Chimeric antigen receptor (CAR) T-cell therapy is the standard of care for relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL). However, more than half of patients fail to achieve durable remission. Identifying predictive biomarkers within the CAR T-cell infusion product (IP) may guide...

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Biology as vulnerability in follicular lymphoma: genetics, epigenetics, and immunogenetics
Lymphoma
 1 min.

 Published on 25/03/2025 |  Original article (Abstract)  | Araujo-Ayala, Ferran et al. | Blood 2025; AOP:10.1182/blood.2024026020

Follicular lymphoma (FL) represents a heterogeneous group of B-cell neoplasms with distinct genetic, epigenetic, microenvironmental, and clinical features. It is the most prevalent indolent non-Hodgkin lymphoma, characterized by a relapsing course and risk of transformation to aggressive diffuse large...

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Circulating tumor DNA in lymphoma: technologies and applications
Lymphoma
 9 min.

 Published on 18/03/2025 |  Original article (Abstract)  | Fu Lina et al. | Journal of Hematology & Oncology 2025; 18(1): 29

Lymphoma, a malignant neoplasm that originates from lymphocytes and lymphoid tissues, has experienced a significant increase in incidence over recent years [1]. The complexity of its pathological types necessitates a comprehensive classification system. The latest World Health Organization (WHO) classification,...

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18F-FDG PET/CT metabolic parameter changes to assess vascular inflammatory response in patients with diffuse large B-cell lymphoma
Lymphoma
 5 min.

 Published on 11/03/2025 |  Original article (Abstract)  | Xie Wenli et al. | BMC Medical Imaging 2025; 25(1): 81

Malignant tumors and cardiovascular disease are the two leading causes of death in humans [1]. Oncology patients may experience vascular toxicity during and after chemotherapy [2]. The diversity of vascular toxicity from oncology treatments, including altered vascular reactivity, vascular thrombosis,...

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