
Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of B-cell lymphomas, comprising approximately 30% of all non-Hodgkin lymphoma cases [1]. This aggressive malignancy primarily affects B-lymphocytes, making rapid and effective therapeutic intervention crucial due to its fast growth rate....

The R-MPV regimen—comprising rituximab, methotrexate, procarbazine (PCZ), and vincristine—followed by reduced-dose whole-brain radiotherapy and high-dose cytarabine, is an established treatment for primary central nervous system lymphoma (PCNSL). However, PCZ is occasionally omitted due to...

Mantle-cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma. Bruton tyrosine kinase inhibitors (BTKi) significantly improve the prognosis of MCL, but their long-term use may induce immunosuppression-related complications, including secondary malignancies. First-generation BTKi such as Ibrutinib...

HIV-infected individuals with advanced disease are prone to severe immunosuppression, a condition commonly referred to as Acquired Immunodeficiency Syndrome (AIDS) [1], particularly a marked reduction in CD4 + T cell counts, which predisposes them to a wide range of opportunistic infections and malignancies...