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Skin Barrier ScienceArchives

Multi layered poly-L-lactic acid (PLLA) treatment of the face using a universal facial grid

 Published on 14/07/2025 |  Original article (Full-text)  | Peter A.C. den Otter et al. | Journal of Cosmetic and Laser Therapy 2025; 27(3): 109-12

A uniform model for the treatment of aging signs of the face using Poly-L-lactic acid is presented. The causes of aging effects on the levels of the bone, the connective tissue, fat pads and the skin are addressed in a single procedure by use of needle or canula. For the treatment of the skin, a facial...

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Light and laser-based therapy in treatment of acne vulgaris: A Clinical Review

 Published on 07/07/2025 |  Original article (Full-text)  | Ishii, Lisa et al. | Journal of the American Academy of Dermatology 2025; AOP:10.1016/j.jaad.2025.06.046

The gold standard of acne vulgaris management remains a stepwise and combination approach with topical and systemic medications. However, it is not uncommon for patients to experience intermittent flares or inadequate control despite optimized medical management. Other patients may experience side effects...

Loss of Bach2 in T cells causes prolonged allergic inflammation through accumulation of effector T cells and disruption of epidermal barrier

 Published on 30/06/2025 |  Original article (Full-text)  | Omori-Miyake, Miyuki et al. | The Journal of allergy and clinical immunology 2025; 155(6): 2009-2021.e6

Bach2 has been suggested to be a risk factor for allergic diseases in previous studies. Because type IV hypersensitivity reactions, including allergic contact dermatitis (ACD), develop through activated T cells, and because the expression of Bach2 is regulated in the development and functional differentiation...

A novel calreticulin of Psoroptes ovis regulated keratinocyte function resulting in host skin barrier dysfunction: implications for involvement in the pathogenesis of psoroptic mange

 Published on 23/06/2025 |  Original article (Full-text)  | Li Yane et al. | Parasites & Vectors 2025; 18(1): 198

Psoroptes ovis, the causative agent of psoroptic mange, is a prevalent ectoparasite affecting both domestic and wild animals worldwide. Its clinical manifestations, including emaciation, scabbing, and skin thickening, ultimately result in significant economic losses and severe welfare concerns...

Basophil-VAMP7 is a vital regulator of skin barrier integrity and chronic itch

 Published on 16/06/2025 |  Original article (Full-text)  | Zhang, Wenhao et al. | The Journal of allergy and clinical immunology 2025; 155(6): 1928-44

Atopic dermatitis (AD) is a multifaceted inflammatory skin disease characterized by chronic itch and acute itch flare (AIF), with basophils playing pivotal roles in both. VAMP7 mediates immune responses; however, its function in basophils remains undefined. We sought to elucidate the role of VAMP7 in...