Skin Barrier ScienceArchives
Skin deep: dermatologic challenges in PCOS through the female lifespan
Skin Barrier Science 1 min.
Polycystic ovary syndrome (PCOS) is a lifelong endocrine-metabolic condition with prominent dermatologic manifestations such as hirsutism, acne/seborrhea, and female pattern hair loss (FPHL), which are frequently the initial complaint for seeking medical attention. This review explores the pathogenesis...
Correlation between ceramide and its metabolites and central precocious puberty: a cross-sectional study
Skin Barrier Science 4 min.
Sphingolipids, a class of lipids containing amino alcohol backbones, are ubiquitous in mammalian cells. Increasing evidence indicates that dysregulation of bioactive sphingolipid signaling not only contributes to the development of metabolic diseases but also mediates their pathological sequelae [1]....
Ruxolitinib Cream As-Needed Monotherapy Demonstrates Sustained Disease and Symptom Control in Patients with Mild to Moderate Atopic Dermatitis: Pooled Analysis from Two Phase 3 Studies
Skin Barrier Science 5 min.
Atopic dermatitis (AD) is a chronic, highly pruritic, inflammatory skin disease [1]. Itch and the resulting sleep disturbance significantly reduce the quality of life in patients with AD [2, 3]. There is a need for treatments that can safely maintain disease and symptom control when used over the long...
Synergistic toxicity in alcohol-associated liver disease and PFAS exposure
Skin Barrier Science 1 min.
Alcohol-associated liver disease (ALD) remains a leading contributor to global morbidity and mortality. Chronic ethanol intake drives hepatocellular damage through multiple mechanisms, such as acetaldehyde-induced cytotoxicity, dysregulated lipid metabolism, oxidative stress, and inflammation. Per- and...
Clinical Efficacy of a Salicylic Acid-Containing Gel on Acne Management and Skin Barrier Function: A 21-Day Prospective Study.
Skin Barrier Science NaN min.
Acne vulgaris is a common skin condition characterized by excessive sebum production, inflammation, and compromised skin barrier function. Effective treatments should target both lesion reduction and skin hydration while maintaining tolerability.Objective: This study aimed to evaluate the efficacy and...
