Skin Barrier ScienceArchives
UDP-glucose ceramide glucosyltransferase promotes radioresistance via membrane reorganization to maintain redox balance in glioblastoma
Skin Barrier Science 8 min.
Glioblastoma (GBM) is a highly aggressive and lethal brain tumor characterized by inevitable recurrence and resistance to standard therapies such as radiotherapy and temozolomide (TMZ) [1, 2–3]. Even after maximal surgical resection and chemoradiation, GBM tumors often relapse within the irradiated...
Anterior segment optical coherence tomography study of the cornea and tear film after systemic isotretinoin treatment in acne vulgaris
Skin Barrier Science 4 min.
Acne vulgaris (AV) is a common dermatological skin disorder. When other treatments for severe cystic AV have failed, isotretinoin (13-cis-retinoic acid) is preferred. Isotretinoin is a first-generation nonaromatic b-carotene retinoid (provitamin A) [1]. Oral isotretinoin results in long-term acne remission...
The mediterranean diet and acne vulgaris: a systematic review and meta-analysis
Skin Barrier Science 5 min.
Acne vulgaris is a chronic skin condition of the pilosebaceous unit with a multifactorial and intricate pathophysiology that includes increased sebum production, androgenic hormonal effects, follicular hyperkeratinization, and bacterial hyperproliferation [1, 2–3]. Acne lesions may range from mild,...
Sphingolipids in Gaucher disease: a systematic review
Skin Barrier Science 8 min.
Given that the product of glucosylceramide (GlcCer) catabolism is ceramide, it is reasonable to assume that cells will produce less ceramide in Gaucher disease (GD), as GlcCer catabolism is impaired by defective acid beta-glucocerebrosidase (GCase) activity. However, ceramide is also generated from the...
Converging paths toward unified therapeutic approaches in atopic dermatitis, vitiligo, and alopecia areata
Skin Barrier Science 1 min.
Emerging evidence reveals significant epidemiologic, genetic, and immunologic connections between atopic dermatitis, vitiligo, and alopecia areata, challenging previously established notions of their distinct pathogenic and molecular signatures. Exploring these commonalities not only enhances our understanding...
