MelanomaArchives
Recurrence risk prediction in resected stage I-III melanoma utilizing circulating tumor DNA
Melanoma 5 min.
Melanoma is a highly malignant neoplasm that arises from melanocytes. Invasion is an important feature of melanoma, which leads to a high risk of metastatic spread and poor prognosis. In patients who underwent surgical resection, the five-year survival rates of stage II and III for were 44.0% and 38.4%,...
CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses
Melanoma 7 min.
Irreversible electroporation (IRE) is an innovative, non-thermal tissue ablation technology that applies high voltage electrical pulses to targeted tumor tissue, leading to massive cell apoptosis [1, 2–3]. Compared to thermal forms of ablation such as radiofrequency ablation, microwaves and high...
Treatment-refractory immune checkpoint inhibitor-induced hemophagocytic lymphohistiocytosis in the setting of adjuvant pembrolizumab for resected stage IIC melanoma: a case report
Melanoma 3 min.
Hemophagocytic lymphohistiocytosis (HLH) is a dysregulated systemic inflammatory state with persistent activation of natural killer (NK) cells, cytotoxic T lymphocytes, and macrophages, leading to elevation of serum proinflammatory cytokines causing immune-related multiorgan damage. HLH can be broadly...
Identification of two distinct uveal melanoma subtypes based on the immune cell infiltration of the primary tumour
Melanoma 4 min.
Uveal melanoma (UM) is the most common intraocular malignancy, accounting for approximately 3% of all melanoma cases [1]. Disease arises from melanocytes in the uvea tract of the eye with the majority of cases affecting the choroid and less frequently the iris and ciliary body. Mean patient age at diagnosis...
