Acral melanoma (AM), defined here as melanoma arising on the palm, sole, or nail apparatus, is a unique subtype of malignant melanoma. It differs from other melanoma subtypes in terms of epidemiology, clinical and pathological features, prognosis, and molecular characteristics [1–3]. Our knowledge...
When a patient presents with malignant melanoma without evidence of an epidermal component, the differential diagnosis may include melanoma of unknown primary (MUP) which can present as palpable lymphadenopathy or as a solitary dermal lesion. As defined by Das Gupta, MUP involves presence of melanoma...
A 43-year-old woman presented with an anorectal mass at which time excision was performed, and biopsy revealed anorectal mucosal melanoma (AM), anal subtype. Postexcision, F-FDG PET/CT identified residual melanoma, confirmed on biopsy. Recurrence was monitored every 3 months using F-FDG, which identified...
Metastatic melanoma carries a poor prognosis, with a 5‐year survival rate around 10%, and distant metastases having a less favorable prognosis than local spread or recurrence [1]. The skin is the most common site involved by metastatic melanoma, observed in approximately in 50%–60% of cases [2]....
Management of patients with cutaneous melanoma (CM) depends on assessing molecular biomarkers that enable personalization of patient treatment. The genetic landscape of melanoma is complex and variable depending on histological subtype, location, and individual characteristics, which affects heterogeneous...