
Gepotidacin, a novel oral antibacterial targeting bacterial DNA gyrase and topoisomerase IV, exhibits potent activity against Escherichia coli and Neisseria gonorrhoeae resistant strains. This systematic review and meta-analysis assessed the efficacy and safety of gepotidacin compared with standard-of-care...

Urothelial carcinoma (UC) is a significant global health concern, ranking as the ninth most common malignancy worldwide and one of the leading causes of mortality among urological cancers [1]. Representing the predominant histological subtype of bladder cancer, UC is characterized by marked biological...

High-risk distal ureteral urothelial carcinoma (UC) is an aggressive malignancy in the lower ureter, known for its potential for local invasion and distant metastasis. Prompt and appropriate surgical intervention is crucial to improving patient outcomes and survival. Among the surgical options for treating...

Immune checkpoint inhibitors (ICIs) have significantly transformed the treatment landscape of urologic malignancies, including bladder cancer, renal cell carcinoma (RCC), and prostate cancer. Despite impressive clinical responses in subsets of patients, the heterogeneity of response highlights the urgent...

Urothelial carcinoma is the most common pathological type of bladder tumor, accounting for approximately 90% of all primary bladder malignancies. Locally advanced or metastatic urothelial carcinoma is generally difficult to cure, and treatment options remain limited. PD-1/PD-L1 immune checkpoint inhibitors...