Others Urological ConditionsArchives
Reduced activin A levels impair urogenital system development and compromise female mouse fertility
Others Urological Conditions 1 min.
Activin A, encoded by the Inhba gene, is a versatile protein crucial for numerous biological processes, and its dysregulation is implicated in various human disorders. However, the perinatal lethality of Inhba knockout mice restricts the delineation of the full extent of this protein's function in the...
Safety profile of enfortumab vedotin plus pembrolizumab in locally advanced or metastatic urothelial carcinoma: a multicenter Japanese cohort study
Others Urological Conditions 1 min.
Enfortumab vedotin plus pembrolizumab (EVP) has shown promising efficacy in locally advanced or metastatic urothelial carcinoma (la/mUC), but real-world data in Japanese patients are limited. We assessed the safety and early efficacy of EVP, with a focus on cutaneous adverse events (AEs). Methods: We...
Neoadjuvant immune checkpoint inhibitors for muscle-invasive urothelial carcinoma: a systematic review and meta-analysis
Others Urological Conditions 1 min.
Muscle-invasive urothelial carcinoma (MIUC) represents one-quarter of cancers and carries morbidity and mortality. Although cisplatin neoadjuvant chemotherapy plus radical cystectomy improves survival, patients may be ineligible due to renal dysfunction or comorbidities. Immune checkpoint inhibitors...
Site and number of metastases predict outcomes in avelumab maintenance for advanced UC: results from meet-URO 25
Others Urological Conditions 5 min.
Urothelial carcinoma (UC) is the most common histological subtype of bladder cancer and other malignancies arising from the urinary tract [1]. While many cases are diagnosed at an early and potentially curable stage, a substantial proportion of patients will eventually develop locally advanced or metastatic...
Bacterial uropathogens, associated factors, and ESBL-producing gram-negative isolates in diabetic patients at Debre Markos comprehensive specialized hospital, Ethiopia
Others Urological Conditions 6 min.
Non-communicable diseases are becoming a global threat that lead to a high rate of morbidity and mortality. Diabetes mellitus(DM) is one of the most prevalent long-lasting, non-communicable, and endocrine system disorder [1]. The 2017 International Diabetics Federation estimated that 451 million (8.4%)...
