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Infective endocarditis and spondylodiscitis-impact of sequence of surgical therapy on survival and recurrence rate

 Published on 30/04/2026 |  Original article (Full-text)  | Carolyn Weber et al. | European journal of cardio-thoracic surgery. Volume 66(1).

To date, there are no standardized treatment algorithms or recommendations for patients with infective endocarditis (IE) and concomitant spondylodiscitis (SD). Therefore, our aim was to analyse whether the sequence of surgical treatment of IE and SD has an impact on postoperative outcome and to identify...

Current status of immunomodulatory therapies in adult sepsis patients: where do we stand?

 Published on 23/04/2026 |  Original article (Full-text)  | Dimitra Papatheodosiou et al. | Expert Review of Anti-infective Therapy 2026; 24(2): 239-57

Despite advances, sepsis remains a leading cause of morbidity and mortality worldwide. Dysregulated host responses are known to characterize sepsis, and while numerous clinical trials using immunomodulatory strategies have been attempted, most fail to show benefit. An important reason for their failure...

Surgical Implications of the 2023 ESC Endocarditis Guidelines Endorsed by EACTS: Bridging Guidelines and Practice

 Published on 16/04/2026 |  Original article (Full-text)  | Manuela de la Cuesta et al. | European journal of cardio-thoracic surgery. Volume 67(7).

Role of the multidisciplinary "Endocarditis Team": All patients with complicated infective endocarditis (IE) should be managed by a specialized Endocarditis Team to improve diagnosis, optimize treatment, and enhance outcomes (Figure 1). Indications for surgery: The main surgical indications for IE include...

Conservative versus surgical treatment of patients with infective endocarditis after transcatheter aortic valve implantation: a systematic review and meta-analysis

 Published on 09/04/2026 |  Original article (Full-text)  | N Pyrpyris et al. | European Heart Journal Supplement. Volume 28(Supplement 3).

Infective endocarditis after transcatheter aortic valve implantation (TAVI-IE) is a rare but serious complication associated with high morbidity and mortality. Strategies for managing TAVI-IE vary significantly, with the optimal therapeutic approach remaining a subject of debate. Therefore, the aim of...

Revising Sepsis Definitions to Better Target and Tailor Sepsis Care

 Published on 02/04/2026 |  Original article (Full-text)  | Michael Klompas et al. | Clinical infectious diseases. Volume 80(6).

How we define sepsis has significant implications for clinical care, quality improvement, and regulatory policies. Current sepsis criteria identify heterogenous patients that vary widely in their clinical syndromes, triggering pathogens, and prognoses; one-third have viral or non-infectious processes...