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TNF-α inhibitor therapy and prosthetic aortic valve endocarditis: a case report

 Published on 11/09/2025 |  Original article (Full-text)  | Raksheeth Agarwal et al. | Future Cardiology 2025; aop:10.1080/14796678.2025.2555777

Tumor necrosis factor-alpha (TNF-α) inhibitors and other biologics used for autoimmune diseases are associated with low-grade immunosuppression. Treatment with these and the presence of prosthetic mechanical cardiac valves both increase the risk of infective endocarditis (IE). However, evidence...

Serum proteomes and their prognostic values in sepsis patients admitted to a medical intensive care unit: a single-center study using SWATH-MS proteomics

 Published on 04/09/2025 |  Original article (Full-text)  | Lee Su Yeon et al. | Annals of Intensive Care 2025; 15(1): 126

Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection [1]. Approximately one-third of critical illness patients admitted to the intensive care unit (ICU) are diagnosed with sepsis [2]. Although advances in critical care management...

Healthcare costs after sepsis: a systematic review

 Published on 28/08/2025 |  Original article (Full-text)  | Chechulina Victoria et al. | Critical Care 2025; 29(1): 380

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection [1]. This syndrome is associated with high in-hospital mortality and initial healthcare costs [2]. Sepsis survivors are at increased risk of hospital readmission, with recent estimates reporting...

Circulating metabolic biomarkers predict incident sepsis: a large-scale population study in the UK Biobank

 Published on 21/08/2025 |  Original article (Full-text)  | Bai Hao et al. | Nutrition Journal 2025; 24(1): 126

Sepsis is recognized as a life-threatening medical condition, characterized by a dysregulated systemic inflammatory response to infection [1]. Global data from 2017 indicate that sepsis affects an estimated 49 million people and causes approximately 11 million deaths annually [1, 2], accounting...