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Spontaneous hepatic rupture after mitral valve replacement for infective endocarditis in pregnancy: a case report

 Published on 11/12/2025 |  Original article (Full-text)  | Wang Zhenzhong et al. | BMC Pregnancy and Childbirth 2025; 25(1): 1278

Liver rupture occurs in approximately 1 in 200,000 pregnancies, mainly associated with acute fatty liver of pregnancy or HELLP syndrome, and rarely without associated liver disease [1]. To our knowledge, this is the first case report that describes spontaneous liver rupture after cardiac surgery with...

Predictive enrichment using biomarkers in studies of critically-ill patients with sepsis: a systematic review

 Published on 04/12/2025 |  Original article (Full-text)  | Van Nynatten Logan R. et al. | Critical Care 2025; 29(1): 503

Sepsis and septic shock remain one of the most common reasons necessitating admission to intensive care units (ICU) [1]. Over past decades, both observational cohorts and pooled trial data demonstrate a steady decline in sepsis mortality, a trend largely attributed to advances in supportive care and...

Reduced plasma levels of Copine 5 correlate with sepsis-induced vascular leakage and mortality in human patients and a murine sepsis model

 Published on 27/11/2025 |  Original article (Full-text)  | Pan Mingliang et al. | Critical Care 2025; 29(1): 496

Sepsis is characterized as life-threatening organ dysfunction caused by a dysregulated host response to infection with concurrent hyper-inflammation and immunosuppression [1]. Although the clinical managements with early adequate antimicrobial medication to control infection and the immediate hemodynamic...

Identification of protein biomarkers to differentiate between gram-negative and gram-positive infections in adults suspected of sepsis

 Published on 20/11/2025 |  Original article (Full-text)  | Irani Shemirani Mahnaz et al. | BMC Infectious Diseases 2025; 25(1): 1576

Sepsis is a life-threatening condition resulting from a dysregulated response to infection, with the risk of rapid progression to septic shock and potentially fatal outcomes without timely recognition and treatment [1]. Bacterial infection is the major cause of sepsis [1], with both gram-negative and...