
Role of the multidisciplinary "Endocarditis Team": All patients with complicated infective endocarditis (IE) should be managed by a specialized Endocarditis Team to improve diagnosis, optimize treatment, and enhance outcomes (Figure 1). Indications for surgery: The main surgical indications for IE include...

Infective endocarditis after transcatheter aortic valve implantation (TAVI-IE) is a rare but serious complication associated with high morbidity and mortality. Strategies for managing TAVI-IE vary significantly, with the optimal therapeutic approach remaining a subject of debate. Therefore, the aim of...

How we define sepsis has significant implications for clinical care, quality improvement, and regulatory policies. Current sepsis criteria identify heterogenous patients that vary widely in their clinical syndromes, triggering pathogens, and prognoses; one-third have viral or non-infectious processes...

Randomized trials of procalcitonin-guided algorithms to discontinue antibiotics in critically ill patients with sepsis report reduced antibiotic duration and possible mortality benefit. However, open-label trial designs, inconsistent algorithm adherence, and unclear stewardship practices have limited...
