Tumor necrosis factor-alpha (TNF-α) inhibitors and other biologics used for autoimmune diseases are associated with low-grade immunosuppression. Treatment with these and the presence of prosthetic mechanical cardiac valves both increase the risk of infective endocarditis (IE). However, evidence...
Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection [1]. Approximately one-third of critical illness patients admitted to the intensive care unit (ICU) are diagnosed with sepsis [2]. Although advances in critical care management...
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection [1]. This syndrome is associated with high in-hospital mortality and initial healthcare costs [2]. Sepsis survivors are at increased risk of hospital readmission, with recent estimates reporting...
Sepsis is recognized as a life-threatening medical condition, characterized by a dysregulated systemic inflammatory response to infection [1]. Global data from 2017 indicate that sepsis affects an estimated 49 million people and causes approximately 11 million deaths annually [1, 2], accounting...