
Sepsis-induced coagulopathy (SIC) represents a prevalent and life-threatening complication of sepsis, substantially contributing to mortality among critically ill patients [1, 2]. Defined by dysregulated coagulation and progressive organ dysfunction, SIC has emerged as a central mediator of adverse outcomes...

Climate change increasingly dominates the global health agenda by altering the spatiotemporal patterns of infectious diseases. A growing body of global evidence shows that rising temperatures, precipitation variability, and ecosystem disruption are reshaping disease dynamics worldwide [1, 2–3]....

Sepsis is a life-threatening condition caused by a dysregulated host response to infection and remains a leading cause of death in intensive care units. Although antimicrobials and supportive care are vital, patient outcomes are hindered by two conflicting immune states: excessive inflammation and immune...

The global population is aging at an unprecedented rate, leading to a growing number of elderly individuals requiring critical care. This demographic shift has resulted in a substantial rise in the proportion of the “oldest old” (≥ 85 years) admitted to intensive care units (ICUs),...

The 2021 Surviving Sepsis Campaign Guidelines strongly recommend healthcare systems use a performance improvement program for sepsis, including sepsis screening [1]. Identification of patients (cases) with sepsis underpins these programs. Yet, multiple clinical criteria exist to operationalize the definitions...