VaccinesArchives
Working toward a single-dose vaccine for rabies post-exposure prophylaxis
Vaccines 1 min.
Rabies is almost universally fatal if not treated before symptoms appear. Fortunately, post-exposure prophylaxis (PEP) is a nearly 100% effective treatment when started soon after rabies exposure. Nevertheless, rabies causes approximately 59,000 deaths annually, predominantly in rural parts of low- and...
Modeling the impact of vaccine dose prioritization strategies during the 2022 mpox outbreak
Vaccines 1 min.
Early in the 2022 mpox outbreak, the US recommendation was to administer two doses of the JYNNEOS vaccine 4 weeks apart. However, because of limited vaccine supply, New York City (NYC) prioritized single dose vaccination. We estimated mpox cases averted by this strategy compared to strategies that prioritized...
Toward elimination of hepatitis A and B in Europe: vaccination successes, challenges, and opportunities
Vaccines 1 min.
Hepatitis B and hepatitis A are vaccine-preventable infections of global concern. Hepatitis B virus (HBV) and hepatitis A virus (HAV) vaccines available in Europe are underutilized in some age groups. While most European countries implemented childhood HBV universal routine vaccination (URV), vaccination...
Can vaccine-preventable disease resurgence be anticipated? Leading indicators and tipping points
Vaccines 1 min.
Vaccination programs have averted millions of childhood deaths, yet vaccine-preventable diseases (VPDs) continue to resurge as coverage declines and pathogen evolution undermines previously successful vaccines. Anticipating resurgence is a public health priority. We review theoretical and empirical advances...
Loss of confidence in vaccines following media reports of infant deaths after hepatitis B vaccination in China
Vaccines 1 min.
China reduced hepatitis B virus (HBV) infection by 90% among children under 5 years old with safe and effective hepatitis B vaccines (HepB). In December 2013, this success was threatened by widespread media reports of infant deaths following HepB administration. Seventeen deaths and one case of anaphylactic...
