VaccinesArchives
Loss of confidence in vaccines following media reports of infant deaths after hepatitis B vaccination in China
Vaccines 1 min.
China reduced hepatitis B virus (HBV) infection by 90% among children under 5 years old with safe and effective hepatitis B vaccines (HepB). In December 2013, this success was threatened by widespread media reports of infant deaths following HepB administration. Seventeen deaths and one case of anaphylactic...
COVID-19 burden in the paediatric population in Latin America during vaccine rollout: a real-world study using national surveillance data
Vaccines 6 min.
Coronavirus disease 2019 (COVID-19) has impacted the health and well-being of children and adolescents worldwide [1]. Although COVID-19 generally has a milder presentation in the paediatric population, severe outcomes, including hospitalisation and death, can still occur, especially among those with...
Vaccine adjuvants as stand-alone immunoprophylaxis in strategies for 100-day rapid responses to future pandemics
Vaccines 1 min.
The COVID-19 pandemic accelerated vaccinology progress, driving rapid vaccine development for infectious and non-infectious diseases. However, challenges persist: malaria, HIV, and dengue lack fully effective vaccines, whereas influenza and tuberculosis face waning efficacy. Emerging pathogens and drug-resistant...
Imprecision in tuberculosis infection outcomes: implications for non-inferiority vaccine trials
Vaccines 1 min.
Randomized trials comparing new vaccines against tuberculosis for use in neonates and infants, for whom Bacille Calmette-Guérin vaccination is established practice, are using tuberculosis infection as the primary endpoint in a non-inferiority design. Markers of tuberculosis infection have imperfect...
Comparing standard versus intensified pneumococcal vaccination regimens in patients with inflammatory bowel disease on biologics: a prospective, multicenter, randomized, open-label study
Vaccines 1 min.
Pneumococcal vaccination is essential for patients with inflammatory bowel diseases (IBD), but its efficacy is reduced in those on antitumor necrosis factor (TNF) or immunosuppressive therapy. This study compared immune responses to standard versus intensified pneumococcal vaccination strategies in IBD...
